Uploaded bySmruti Patanaik
Leptin and obesity cycle
Leptin, a peptide hormone discovered in 1994, is secreted by adipocytes and plays a crucial role in regulating food intake as part of a feedback loop related to body fat depots. The defective ob/ob gene in mice has linked leptin to obesity, while the knockout of the db/db gene results in decreased leptin receptors, contributing to leptin resistance and obesity. Obesity is recognized as a global health problem, highlighting the significance of leptin in understanding and addressing this issue.
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Leptin and obesity cycle
- 1. LEPTIN & OBESITY Dr.Smrutiranjan Patanaik
- 2. OBESITY – A GLOBAL HEALTH PROBLEM RECENT LIPOSTATIC HYPOTHESIS HAS GIVEN ATTENTION TO LEPTIN DEFECTIVE OB/OB GENE IN MICE REVEALS ASSOCIATION OF LEPTIN WITH OBESITY KNOCKOUT OF DB/DB GENE PRODUCES DECREASE IN LEPTIN RECEPTORS LEPTIN RESISTANCE IS ASSOCIATED WITH OBESITY
- 4. A PEPTIDE HORMONE 167 AMINO ACIDS M.wt. 16kDa SECRETED BY ADIPOCYTES DISCOVERED BY FRIEDMAN IN 1994
- 12. LEPTIN OPERATES AS PART OF A FEEDBACK LOOP BY WHICH THE SIZE OF THE BODY FAT DEPOTS CAN OPERATE THROUGH A HUMORAL LINK TO REGULATE FOOD INTAKE
- 13.