Uploaded bySultan Mahmud
Loctril (Montelukast)
The document discusses asthma, highlighting it as a chronic airway disease characterized by inflammation and difficulty in breathing, often triggered by various allergens and irritants. It introduces montelukast (Loctril), a medication that acts as a leukotriene receptor antagonist to alleviate asthma and allergic rhinitis symptoms, along with dosage guidelines. The document also presents a market analysis of respiratory medications, emphasizing the importance of targeted marketing to healthcare professionals for the effective prescription of Loctril.
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The presentation is introduced by Sultan Mahmud, Senior Product Executive.
Discussion on Respiratory Tract Diseases, focusing on asthma and allergic rhinitis.
Slide introduces asthma as a chronic lung disease affecting airways.
Asthma leads to inflamed airways causing difficulty in airflow; key insights from AAAAI.
Key symptoms: coughing, shortness of breath, chest tightness, and wheezing.
Common asthma triggers include allergens, irritants, illness, exercise, and stress.
Exercise can trigger asthma symptoms, peaking 5 to 20 minutes after activity.
NSAIDs can trigger asthma in 2-25% of adults; this type is usually severe.
Allergic asthma involves airway obstruction and typical allergy symptoms, accounting for 60% of cases.
Nighttime asthma symptoms can be more severe due to circadian rhythm influences.
Defines allergic rhinitis as an allergic reaction often triggered by pollen.
Common symptoms include sneezing, runny/stuffy nose, itchy nose, and sore throat.
Key allergens include pollen, dust mites, animal dander, cat saliva, and mold.
Perennial rhinitis symptoms occur year-round, primarily from dust mites and pets.
Strategies to prevent asthma and allergic rhinitis are introduced.
Marketing the product 'Montelukast 10 mg Tablet' for better respiratory health.
Explanation of the brand name 'LOCk LeukoTRIenes' by Montelukast.
Montelukast is an oral leukotriene receptor antagonist, inhibiting CysLT1 receptor.
Montelukast is classified as a potent anti-asthmatic medication.
Leukotrienes promote inflammation causing airway constriction and excess mucus.
Leukotrienes are released in asthmatics upon exposure to asthma triggers.
Loctril binds leukotriene receptors, inhibiting bronchoconstriction and asthma symptoms.
Loctril's therapeutic uses for asthma and allergic rhinitis are outlined.
Dosage recommendations for asthma and allergic rhinitis for adults and adolescents.
Information on Loctril's safety category during pregnancy.
Overview of product name, generic name, strength, and price for Loctril.
Illustrative comparison of breathing challenges in fish and asthma patients.
Market analysis providing key figures on respiratory market and growth.
Breakdown of growth shares in the respiratory market, highlighting Montelukast.
Overview ofRx unit share and competitor positioning in the market.
Loctril tablet positioned as a choice for chronic asthma and allergic conditions.
Identification of specialist doctors who can prescribe Loctril.
Asthma increases cardiovascular disease risk; Montelukast may mitigate these risks.
Unique benefits of Montelukast include effective symptom reduction for asthma and rhinitis.
Strategies for effective marketing and prescription of Loctril among targeted doctors.
Plan for monitoring prescriptions and strategies to enhance sales of Loctril.
The presentation concludes with a thank you note.
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Loctril (Montelukast)
- 1. Presented By: Sultan Mahmud SeniorProduct Executive Cell: 01713374701 Welcome
- 2. Discussion on Respiratory TractDiseases
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- 4. What is Asthma? Asthma is a chronic disease involving the airways in the lungs. These airways or bronchial tubes, allow air to come in and out of the lungs. If you have asthma your airways are always inflamed. They become even more swollen and the muscles around the airways can tighten when something triggers your symptoms. This makes it difficult for air to move in and out of the lungs. According to American Academy of Allergy Asthma & Immunology (AAAAI)
- 5. Coughing Shortness of breath Chesttightness Wheezing Asthma Symptoms
- 6. Asthma Triggers Outdoorallergens- such as pollens from grass, trees and weeds Indoor allergens- such as pet dander, dust mites and mold Certain drugs and food additives Irritants in the air- such as smoke, chemical fumes and strong odors Colds, the flu or other illnesses Exercise Stress Weather conditions- such as cold air or extremely dry, wet or windy weather
- 7. • Exercise-induced asthmais triggered by exercise or physical exertion. Many people with asthma experience some degree of symptoms with exercise. With exercise-induced asthma, airway narrowing peaks 5 to 20 minutes after exercise begins Exercise-Induced Asthma
- 8. Aspirin-induced Asthma Takingaspirin or other NSAIDs (non-steroidal anti- inflammatory drugs) triggers an asthma. Between 2% and 25% of adults with asthma are sensitive to aspirin. Aspirin-induced asthma is more common in adults than children. This type of asthma is usually severe.
- 9. This asthma typeaccounts for nearly 60 percent of all asthma. It involves airway obstruction and typical asthma symptoms often associated with allergies and triggered by allergens. Examples of common triggers include pollens, molds, dust mites and animal dander. Allergic Asthma
- 10. Night time asthma,also called nocturnal asthma, is a common type of the disease. If you have asthma, the chances of having symptoms are much higher during sleep because asthma is powerfully influenced by the sleep-wake cycle (circadian rhythms). Your asthma symptoms of wheezing, cough, and trouble breathing are common and dangerous, particularly at nighttime. Night time (Nocturnal) Asthma
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- 12. An allergen that causes an allergic reaction. Allergic rhinitis, is an allergic response to specific allergens. Pollen is the most common allergen in seasonal allergic rhinitis. These are allergy symptoms that occur with the change of seasons. What is Allergic Rhinitis?
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- 16. So, To Prevent Asthma and Allergicrhinitis…
- 17. …Introducing Breathe better, Livebetter Opso Saline… Montelukast 10 mg Tablet
- 18. Justification of BrandName LOCk LeukoTRIenes by MonteLukast
- 19. Montelukast is aselective and orally active leukotriene receptor antagonist that inhibits the Cysteinyl leukotriene CysLT1 receptor. Each 10 mg film-coated Loctril tablet contains 10.4 mg Montelukast sodium, which is equivalent to 10 mg of Montelukast. Loctril Tablet
- 20. Montelukast is APotent Leukotrienes Receptor Antagonist Anti Asthmatic Therapeutic Class of Loctril Tablet
- 21. Leukotrienes are anaturally occurring chemical substance (Autacoids) that promotes an inflammatory response. When produced and released in the body, this chemical causes airway constriction, the tightening of muscles and excess mucus and fluid. What are Leukotrienes?
- 22. When Leukotrienes areReleased? If anyone breathe an asthma triggers, the body of asthmatics person release Leukotrienes.
- 23. Mechanism of Actionof Loctril Phospholipids Arachidonic acid COX (Cyclooxy genase) 5-lipooxygenease PG Thromboxane LeukotrienesLeukotrienes Binds with Leukotriene Receptor LoctrilLoctril 1. Causes bronchoconstriction 2. Increases mucus secretion 3. Increases Vascular permeability 4. Causes edema Asthma Binds with Cystinyl Leukotriene receptor that inhibits Asthma symptoms
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- 25. Dosage and administrations Forasthma - Take once daily in the evening: One 10-mg tablet for adults and adolescents 15 years of age and older For exercise-induced asthma - Take at least 2 hours before exercise, but not more than once daily: One 10-mg tablet for adults and adolescents 15 years of age and older. For allergic rhinitis - Take once daily at about the same time each day: One 10-mg tablet for adults and adolescents 15 years of age and older
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- 27. Product Brief Product Name Generic NameStrength Dosage Form Pack Size TP TP+VAT MRP/ box MRP/ Tablet Loctril® Montelukast 10 mg Tablet 10X3 339.58 393.91 453.00 15.10
- 28. Dear Sir/Madam In thisvisual you are watching that a fish is facing challenge to take breathe due to lack of watery environment like that it is also challenge to prevent the root cause of Asthma & Allergic Rhinitis
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- 36. Market Analysis (IMS_MAT_2017) CompanyValue (Cr.) Share Growth Respiratory market 1739 100.00 11.67 Montelukast 392 22.54 16.04 1 Monas ACME 83 21.20 21.82 2 Montair Incepta 63 15.95 19.33 3 Provair Unimed 37 9.41 17.83 4 M-kast Drug 30 7.57 155.63 5 Telukast General 23 5.86 0.79 6 Trilock Opsonin 22 5.65 12.91 7 Reversair ACI 20 5.13 108.22 8 Lumona Eskeayf 18 4.56 3.29 9 Aeron Health care 12 3.06 50.00 10 Montene Square 10 2.66 -47.89
- 37. Brand Company RxUnit share (%) Monas ACME 18.22 Trilock Opsonin 17.96 Montair Incepta 9.50 M-Kast Drug-Intl 7.65 Reversair ACI 5.56 Telukast General 5.53 Competitors’ analysis (4P_ Unit_Share_Jan’17)
- 38. Product positioning Loctril® Tablet isthe drug of choice for the Chronic Asthma & allergen induced Broncho constriction.
- 39. Speciality Wise: 1. ChestSpecialist 2. Medicine Specialist 3. Cardiologist 4. ENT Specialist 5. Skin & VD Specialist 6. GP 7. Doctor Cum Chemist 8. RMP Target Doctors of Loctril
- 40. Ans: The pathophysiologyprocesses of asthma may also increase the risk of other disease involving inflammatory processes, such as cardiovascular disease (eg.) atherosclerosis by generating inflammatory biomarker CRP (Carbon reactive protein), IL-6 (Interleukin 6), LDL-C (Low density lipoprotein C), triglyceride etc. Asthma patients are 43% more likely to have heart disease than non-asthmatics. 36% more likely to have high blood pressure than non-asthmatics. Montelukast Lowers the CVD risk of asthma patients. So, Loctril is the suitable treatment option for cardiologist. Why Montelukast can be the suitable option for Cardiologist?
- 41. • Effectively blocksCystinyl Leukotriene receptor • Significantly reduces Day and Night time Asthma symptoms • Effectively reduces Allergic rhinitis symptoms • Better than Salmeterol in bronchodilation Unique selling point
- 42. • Ensure adequateshelving of Loctril® tablet in front of nearest all chemist shops, clinics and institutions of the targeted doctors. • Give special emphasis to the Chest Specialist, Medicine Specialist because they have greater scope of prescribing Loctril® . • Ensures effective outcome of Loctril® samples by ensuring huge number of prescriptions from every potential prescribers. • Focus should be given to RMPs, PCs as there is also huge opportunities to generate Rx and sales from these physicians. Actions to be taken
- 43. • Strong monitoringover the prescribers of Monas (Acme), Montair (Incepta), Provair (Unimed), M-kast (Drug Int), Trilock (Opsonin), Telukast (General), Lumona (Eskeayf), Reversair (ACI), Montene (Square), Aeron (Healthcare), Monocast (Beximco), Montril (Aristo), Odmon (Renata) and convince them to prescribe Loctrol® . Actions to be taken
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