Madhavi
- 1. MADHAVI TIPPANI Arlington, TX Email: [email protected] Cell: +1(469) 525 7794 https://www.linkedin.com/in/madhavi-tippani-51931254 SUMMARY: Biomedical Engineer, proficient in application development/testing/deployment and code generation. Experienced in data collection/processing, statistical data analysis with proven analytical and problem solving skills. Skilled at medical image/signal processing (image reconstruction, segmentation, calibration etc.), and troubleshooting/preventive maintenance, root cause analysis. EDUCATION: The University of Texas at Arlington and the University of Texas Southwestern Medical Center, Dallas Master of Science in Bioengineering andBiomedicalEngineering CGPA-4.0/4.0 Aug’2014 – May’2016 Jawaharlal Technological University, India Bachelor of Technology in Biomedical Engineering CGPA-3.3/4.0 Sep’2009 – May’2013 FUNCTIONAL EXPERTISEandSKILLS: MATLAB andSIMULINK, R, Python, SQLite, LabVIEW, SolidWorks, C, GPUprogramming, MS Office Suite, Image J, DSP, AutoCAD, Pho toshop, EEGLAB, GMP, GLP, GCP, FDA, and ISO Regulations, Hypothesis Testing (F, T, P tests etc.), Documentation, PROFESSIONAL EXPERIENCE: Research Programmer - Ophthalmology department, UTSouthwestern MedicalCenter, Dallas, Texas. Oct’16 – Present Recreated the IMAGEJ Directionality plugin in MATLAB to overcome the speed & memory drawbacks in IMAGEJ. Developed a tool to perform correlation analysis on corneal microscopic (in vitro and in vivo) data to validate that cell patterning depends on collagen organization, generated and presented the analysis reports. Study the changes in gene andprotein expression during the regenerative phase of healing in the rabbit cornea, to form the base for finding novel therapies to treat corneal scarring (major cause of blindness) in humans. Design database and data transfer protocols for time efficient data processing and maintaining inventory. Effectively participate with groups to come upwith novelsolutions to the engineering problems thatevolve during design process. Volunteer data analyst - Bioengineering department, UTArlington, Texas. Jul’16 – Sep’16 Collected EEG data from controlgroupbefore andafterthe LLLT(Low-LevelLaser Treatment) andanalyzedthe signals on EEGLAB (MATLAB) to prove the positive effects of laser treatment overdisabledveterans. Designeda FFTbased bandpass filter for the EEG signals for noise reduction andrecruits human subjects for the study. Research Assistant - Ophthalmology department, UTSouthwestern MedicalCenter, Dallas, Texas. Sep’15 – May’16 Installed system software following manufacturer’s manual and performed routine tests to ensure efficient results. Designed protocols and developed algorithms for 2D and 3D image reconstruction to access corneal pathology and monitor the corneal response to various treatments. Programmed User defined MATLAB functions for decoding (DICOM, Volume) header files and perform signal processing. Deployed a GUI based tool using MATLAB compiler, for quantitative data analysis of 3-Dimensional confocal imaging in vivo. Research and Laboratory Assistant - Bioengineering department, UT Arlington, Texas. Oct’14 – May’15 Developedprotocols for optimalprobe geometry (with maximum laser diodes and detectors) for high-resolution images that help surgeons differentiate the cancer tissue from normal tissue. Designed a 3D model of probe (on SOLIDWORKS) and developed the mold on a glass plate for data collection. Performed Data collection, Data scrubbing, Data analysis (F and T Tests), Data modeling and Data visualization. Constructedphantoms of different concentration that mimic the cancerous and normal tissues to study the conduction of light. Collaboratedwith technicians: provided themthe timely equipment performance anddocumented the machine technical errors. Sales Executive -Aspirejobz.comServices Pvt. Ltd., Hyderabad, India. Dec’13 – Jun’14 Achieved increased productivity as a team lead (team of 4 members). Implemented improved marketing strategies andmarketedcompany products andservices, thus increasing company sales by 8%. Coordinated work schedules with clients and submitted daily logs to client for review. Intern, Biomedical Technician - Care Hospitals, Hyderabad, India. May’12 – Jun’12 Trainedinterns on hospitalregulations, patient care protocols, hazardous chemicals, andmedicallab recordpolicies. Performed testing, root cause analysis, system restoration of medical equipment (MRI, CT, Autoclaves, Sterilizers, Ultrasound, anesthesia machines, surgical equipment, X-ray etc.) and documented their specifications with working. Evaluated system life expectancy and worked on spare parts replacement along with repair documentation.
- 2. PROJECTS Image processing and 3D reconstruction of MRI Brain images Developed MATLAB code to display 2D and 3D contour mapof tumor and brain tissue to visualize the approximate position andsize of tumor in the brain. It also displays the montage viewof 53 consecutive brain images. Documentedthe project with comments on the code. Corneal Image Processing Analytical tool Developed an analytical tool on MATLAB to study the cellular events of wound healing after a corneal surgery or an infection and generate an analysis report (text file) on it. The tool was testedusing cornealdata of mice andrabbits collectedthrough in vivo confocal microscope. The tool has features (built with User defined functions) allowing a user to: - Input Volume files of different sizes froma confocalmicroscope andproject side, front, topand3Dviews of the 2Dcornealimage stack - Pick a desired Region of Interest (ROI) from the stack and perform analysis such as smoothening with different masks - Calculate the stromal haze area from the generated intensity curve; calculate the epithelial, stromal and endothelial thicknesses Wireless Data Communication and Energy Transfer for Implantable Devices Developeda magnetic coilto achieve non-invasive energytransfer into the implantable devices, toavoidmultiple surgeries for recharging the implantable. ‘Witricity’, a phenomenon of magnetic resonance is proposedto exchange energy efficiently between strongly coupled resonant objects in a certain range. Additionally, RF communication was establishedwith the implantable device using a microcontroller AT89C52 (programmed using Keil microvision 3) to modify the operational parameters as per the requirements Study the dependency of exercise levels on disease duration The main objective for carrying out the study is to check if the improvement in exercise duration is dependent on the patient’s disease history. Regression analysis was performed at 5% level of significance, a linear relationship with nega tive correlation between the “disease duration”, andthe “percentage improvement in exercise” was observed.i.e. with increase in diseaseduration the improvement in exercise decreases. Segmentation of Heart structure from surroundings Segmentation techniques like Thresholding, Region Growing, Erosion, Dilation, Opening andClosing etc. were performedon a CTheart image and the results were compared to check the efficient technique. Segmentation was performed to examine the contrast-enhanced heart by eliminating the additional structures like bones and parts of large blood vessels of lung surrounding the heart and parts of patient table. Study on effect of cancer severity on lifespan of patients Performedstatisticaldata analysis on the data set containing an assay on cutaneous melanoma (malignant cancer). Hypotheses testing was performedin ‘R’, F-tests andT-tests were performedon all combinations of data categories (disease severity levels) andconcluded that average lifetime decreased with increased severity. Performed normality check and concluded the lifetime of patient follows approximately normal distribution. Documented the results of five number summary, boxplot, normality and hypotheses tests. Frequency Domain Photon migration in tissue DemonstratedFrequencyDomain opticalmigration technique by measuring the absorption coefficient andreducedscattering coefficient of 1% concentration intralipid using a laser (633nm, 90MHz). Laboratory safety rules for using laser were followed and learned side effects of laser. Study of effects of growth factors on cell migratory patterns Based on the pilot data, a hypothesis was established that a) PDGF would stimulate corneal keratocyte migration with dentritic morphologies that are co-alignedwith collagen fibrils (through directionality analysis andorientation index on each angle in the data); b) TGF-β will induce myofibroblast transformation without alignment to collagen fibrils. LabView projects. - Image Acquisition andProcessing – developeda VI to acquire andstore video images andprocess them, Implementation of edge detection algorithm in LabVIEW. - Interfaced photo detector with LabView and plotted SNR of photo-detector, to measure the profile of a collimated laser beam. - Signal Acquisition and Processing using LabView and DAQ card – developed a VI to generate waveform and display frequency spectrum and a VI to acquire analog signal and display frequency spectrum. - Developed a VI (User Interface) with all prompts for temperature conversion from Fahrenheit to Celsius and vice versa.