The median nerve originates from the brachial plexus and innervates several important muscles in the forearm and hand. It can be affected by lesions or compressions in various locations. A high lesion of the median nerve in the axilla or arm causes paralysis of all median-innervated muscles and sensory loss in the palmar and digital distributions. Compression of the median nerve in the pronator teres muscle causes pain and weakness of the thenar muscles. Anterior interosseous nerve syndrome results from damage to the largest median nerve branch, causing weakness of specific finger flexors. Carpal tunnel syndrome occurs from median nerve compression in the wrist, demonstrated through electrodiagnostic studies.