- Prejith Philip Chacko
- Pharm d
Adherence
‱ Defined by the WHO as “ the extent to which a persons
behaviour {in} taking medications
. Corresponds with agreed
recommendations from a health care provider
.”
‱ -world health organization
Medication adherence
‱ The act of filling a new prescription for the first time, or refilling
prescriptions on time.
‱ The extent to which patients take medications as prescribed by
health care providers.
Benefits of Medication Adherence
‱ Enhances patient safety.
‱ Decreases health care costs.
‱ Improves long-term therapies and outcomes.
‱ Good investment for tackling chronic conditions
compliance
‱ The term compliance has come into disfavour coz it suggests
that a person is passively following doctors orders, rather than
actively collaborating in the treatment process.
‱ Adherence on the other hand, requires the persons agreement
to the recommendations for therapy.
‱ So this concludes that compliance is defined as the act of taking
medications as the doctor intended
‱ Correct medication.
‱ Correct amount of medication.
‱ Correct time of day.
‱ Correct length of time.
Adherence & compliance is related to
‱ Knowledge & beliefs about illness.
‱ Motivation to get better.
‱ Confidence in ability to help oneself get better.
‱ Expectation about the outcome of treatment & results from not
being adherent.
Medication non adherence include:-
‱ Fail to fill the first prescription.
‱ Fail to refill the prescription as
directed.
‱ Skipping doses.
‱ Stopping the medications too
soon.
‱ Taking the doses at the wrong
time.
‱ Taking medication with foods,
drinks or other medications it
shouldn’t be used with.
‱ Taking expired medication.
‱ Storing medications in the
wrong place.
‱ Using devices improperly like
inhalers.
Barriers to Taking Your Medications:
‱ Can’t always see or feel the benefits of your medications
‱ Side effects
‱ Unsure what your medication is being used for
‱ Busy schedule or lifestyle
‱ Multiple medications, with multiple doses per day
‱ Hard to remember
‱ Concerned about risks of your medications
‱ Don’t feel like you need the medication
‱ Cost
What happens when you don’t take
medications as prescribed?
‱ Your medications won’t work as well, you won’t feel better
‱ Your doctor may think it isn’t working and add an additional
medication
‱ You may feel worse
‱ Increased healthcare spending
What happens when you don’t take
medications as prescribed? (cont.)
‱ Potential harm- both from too much and not
enough of your medication
‱ The cause of 33-69% of medication related hospital
admissions
‱ Average length of stay in a hospital, due to non-
adherence is 4.2 days
‱ Preventable deaths due to non-adherence are
estimated to be 125,000 each year
The Five Dimensions Of Non-adherence
‱ Defines adherence as a multidimensional phenomenon
determined by the interplay of five sets of factors.
‱ A holistic approach to address improve medication adherence.
‱ These dimensions interact with one another.
‱ Are patients solely responsible for taking their treatments?
Socio-economic factors
‱ Poverty
‱ Illiteracy
‱ Unemployment
‱ Family dysfunction
‱ High cost of transport
‱ High cost of medication
‱ Low level of education
‱ Poor socioeconomic status
‱ Unstable living conditions
‱ Long distance from treatment centre
Condition related factors
‱ Disability level
‱ Follow-up treatment
‱ Emphasis on adherence
‱ Available effective treatments
‱ Progression /severity of the disease
‱ Co-morbidities (e.g. Depression and drug/alcohol abuse
Therapy-Related factors
‱ Side-effects
‱ Treatment duration
‱ Available medical support
‱ Complex medical regimen
‱ Previous treatment failures
‱ Immediate beneficial effects
‱ Frequent changes in treatment
Pt related factors
‱ Forgetfulness
‱ Low motivation
‱ Psychosocial stress
‱ Disbelief in the diagnosis
‱ Low treatment expectations
‱ Low attendance at follow-up
‱ Lack of acceptance of monitoring
‱ Disease symptoms and treatment
‱ Hopelessness and negative feelings
Health systems factors
‱ Short consultations
‱ Poor health services
‱ Interventions for improving it
‱ Overworked health care providers
‱ Poor medication distribution systems
‱ Inadequate training for health care providers
‱ Lack of incentives and feedback on performance Lack of knowledge on
adherence and of effective
‱ Weak capacity of the system to educate patients and provide follow-up
‱ Inability to establish community support and self-management capacity
strategies to Improve Med. Adherence
‱ The SIMPLE approach
‱ S – Simplify the regimen
‱ I – Impart knowledge
‱ M– Modify patient beliefs and behavior
‱ P – Provide communication and trust
‱ L – Leave the bias
‱ E – Evaluate adherence
S—Simplify the Regimen
‱ Encourage use of adherence aids.
‱ Investigate customized packaging for patients
‱ Adjust timing, frequency, amount, and dosage
‱ Match regimen to patient’s activities of daily living
‱ Consider changing the situation vs. changing the patient
‱ Avoid prescribing medications with special requirements
‱ Recommend taking all medications at the same time of day
I—Impart Knowledge
‱ Advise on how to cope with medication costs
‱ Focus on patient-provider shared decision making
‱ Involve patient’s family or caregiver if appropriate
‱ Keep the team informed (physicians, nurses, pharmacists)
‱ Provide all prescription instructions clearly in writing and verbally
‱ Reinforce all discussions often, especially for low-literacy patients
‱ Suggest additional information from Internet for interested
patients
M—Modify Patient Beliefs and Behavior
‱ Address fears and concerns
‱ Provide rewards for adherence
‱ Empower patients to self-manage their condition
‱ Ask patients about the consequences of not taking their
medications
‱ Have patients restate the positive benefits of taking their
medications
‱ Ensure that patients understand their risks if they don’t take
their medications
P—Provide Communication and Trust
‱ Use plain language
‱ Practice active listening
‱ Provide emotional support
‱ Improve interviewing skills
‱ Elicit patient’s input in treatment decisions
L—Leave the Bias
‱ Develop patient-centered communication style
‱ Acknowledge biases in medical decision making
‱ Understand health literacy and how it affects outcomes
‱ Address dissonance of patient-provider, race-ethnicity, and
language
‱ Examine self-efficacy regarding care of racial, ethnic, and social
minority populations
E—Evaluating Adherence
‱ Self-report
‱ Ask about adherence behavior at every visit
‱ Periodically review patient’s medication containers, noting
renewal dates
‱ Use biochemical tests—measure serum or urine medication
levels as needed
‱ Use medication adherence scales— e.g.
‱ Morisky-8 (MMAS-8), Medication Possession Ratio (MPR),
‱ Proportion of Days Covered (PDC)
MEASURING ADHERENCE
‱ There are several ways to measure medication adherence.
‱ 1.Medication event monitoring systems (MEMS):These are the
most accurate method of measuring adherence because they
record the date and time the medication bottle was opened
through microprocessor technology embedded in the cap.
Advantages with microprocessor:
‱ 1. erroneous/not faith/falls., because patient may remove more
than one dose
‱ 2.Very expensive & different devices are needed for each
medication
‱ 3.Therefore it is an impractical way to determine adherence in
clinical practice.
‱ 2.Patient self-reports is easiest method when adherence is being
assessed, open-ended questions should be asked. Instead of
asking, “Are you taking your medications?” the HCP should
phrase the question along the lines of, “How many times in the
past week (month) have you skipped your medications?
‱ Pill counts
‱ 4.Pharmacy databases or refill rates, and
‱ 5.Blood levels which also are employed in research, are more
feasible options for clinical practice
‱ 6.Morisky’s Medication Adherence Scale (MMAS) It was
designed to distinguish poorly adherent patients from those
with medium to-high adherence to their antihypertensive
regimen
‱ MMAS consists of questions addressing multiple reasons for
non-adherence.. e.g., because regimen complexity can lead to
noncompliance. The scale contains a question assessing whether
the patient feels hassled (trouble/Tense) about his or her
regimen
‱ Since patients tend to give their HCPs positive answers to
please them, the questions in Morisky’s study were phrased to
avoid this bias.
‱ Each question measures a specific medication taking behavior
rather than adherence or compliance behavior.
What patients can do to improve your
adherence:
‱ Make a schedule
‱ Put them in a place that’s easy for you to remember
‱ Include in your daily routine (meal, shower, brush teeth)
‱ Keep a current list of your medications
‱ Set alarms (there’s an app for that)
‱ Use re-fill reminders and auto-fill options at your pharmacy
‱ Choose ONE pharmacy, instead of using multiple pharmacies
‱ Learn more about your medications
Things you should know about your
medications:
‱ Name of medication and what it’s being used for
‱ How long you will be taking the medication
‱ How you should take the medication, including how many times
a day and how often
‱ Should you be avoiding any foods, medications, or activities
while on this medication?
‱ Side effects to look for and what to do if they happen
‱ Where to store your medications
What can your pharmacist do to help?
‱ Inform you about your medications
‱ What your medication is used for
‱ What to expect from using medication
‱ When will it start to work
‱ Will you notice any changes?
‱ Side effects to watch out for
‱ Answer any of your medication questions
What can your pharmacist do to help?
‱ Recommend ways to help you remember to take medications
Pill box Bubble packs Apps
What can your pharmacist do to help?
‱ Fit medications into your schedule
‱ Come up with a schedule, using your daily routines
‱ Consider a medication that may work for a longer period of time
‱ Recommend storage options for medications when traveling
‱ Cost
‱ Cost savings/ discount programs
‱ Look for a similar medication that may cost less
‱ Avoid side effects
‱ Prevent diseases from getting worse
What can your pharmacist do to help?
‱ Medication Therapy Management (MTM)
‱ Appointment with your pharmacist
‱ Bring in all medications and over the counter
products (vitamins/herbals)
‱ Pharmacist reviews all of your medications
‱ Interactions
‱ Side effects
‱ Cost savings
‱ Adherence and compliance
‱ Increase your knowledge of your medications
‱ Answer questions
Always remember

‱ Non-adherence and non-compliance is common
‱ You can have an impact in your health
‱ The reasons people don’t take medications are different for each
person
‱ Be honest and open with your pharmacists and doctors
‱ Pharmacists want to help you overcome barriers to adherence and
compliance

Medication adherence

  • 1.
    - Prejith PhilipChacko - Pharm d
  • 2.
    Adherence ‱ Defined bythe WHO as “ the extent to which a persons behaviour {in} taking medications
. Corresponds with agreed recommendations from a health care provider
.” ‱ -world health organization
  • 3.
    Medication adherence ‱ Theact of filling a new prescription for the first time, or refilling prescriptions on time. ‱ The extent to which patients take medications as prescribed by health care providers.
  • 4.
    Benefits of MedicationAdherence ‱ Enhances patient safety. ‱ Decreases health care costs. ‱ Improves long-term therapies and outcomes. ‱ Good investment for tackling chronic conditions
  • 5.
    compliance ‱ The termcompliance has come into disfavour coz it suggests that a person is passively following doctors orders, rather than actively collaborating in the treatment process. ‱ Adherence on the other hand, requires the persons agreement to the recommendations for therapy.
  • 6.
    ‱ So thisconcludes that compliance is defined as the act of taking medications as the doctor intended ‱ Correct medication. ‱ Correct amount of medication. ‱ Correct time of day. ‱ Correct length of time.
  • 7.
    Adherence & complianceis related to ‱ Knowledge & beliefs about illness. ‱ Motivation to get better. ‱ Confidence in ability to help oneself get better. ‱ Expectation about the outcome of treatment & results from not being adherent.
  • 8.
    Medication non adherenceinclude:- ‱ Fail to fill the first prescription. ‱ Fail to refill the prescription as directed. ‱ Skipping doses. ‱ Stopping the medications too soon. ‱ Taking the doses at the wrong time. ‱ Taking medication with foods, drinks or other medications it shouldn’t be used with. ‱ Taking expired medication. ‱ Storing medications in the wrong place. ‱ Using devices improperly like inhalers.
  • 9.
    Barriers to TakingYour Medications: ‱ Can’t always see or feel the benefits of your medications ‱ Side effects ‱ Unsure what your medication is being used for ‱ Busy schedule or lifestyle ‱ Multiple medications, with multiple doses per day ‱ Hard to remember ‱ Concerned about risks of your medications ‱ Don’t feel like you need the medication ‱ Cost
  • 10.
    What happens whenyou don’t take medications as prescribed? ‱ Your medications won’t work as well, you won’t feel better ‱ Your doctor may think it isn’t working and add an additional medication ‱ You may feel worse ‱ Increased healthcare spending
  • 11.
    What happens whenyou don’t take medications as prescribed? (cont.) ‱ Potential harm- both from too much and not enough of your medication ‱ The cause of 33-69% of medication related hospital admissions ‱ Average length of stay in a hospital, due to non- adherence is 4.2 days ‱ Preventable deaths due to non-adherence are estimated to be 125,000 each year
  • 12.
    The Five DimensionsOf Non-adherence ‱ Defines adherence as a multidimensional phenomenon determined by the interplay of five sets of factors. ‱ A holistic approach to address improve medication adherence. ‱ These dimensions interact with one another. ‱ Are patients solely responsible for taking their treatments?
  • 13.
    Socio-economic factors ‱ Poverty ‱Illiteracy ‱ Unemployment ‱ Family dysfunction ‱ High cost of transport ‱ High cost of medication ‱ Low level of education ‱ Poor socioeconomic status ‱ Unstable living conditions ‱ Long distance from treatment centre
  • 14.
    Condition related factors ‱Disability level ‱ Follow-up treatment ‱ Emphasis on adherence ‱ Available effective treatments ‱ Progression /severity of the disease ‱ Co-morbidities (e.g. Depression and drug/alcohol abuse
  • 15.
    Therapy-Related factors ‱ Side-effects ‱Treatment duration ‱ Available medical support ‱ Complex medical regimen ‱ Previous treatment failures ‱ Immediate beneficial effects ‱ Frequent changes in treatment
  • 16.
    Pt related factors ‱Forgetfulness ‱ Low motivation ‱ Psychosocial stress ‱ Disbelief in the diagnosis ‱ Low treatment expectations ‱ Low attendance at follow-up ‱ Lack of acceptance of monitoring ‱ Disease symptoms and treatment ‱ Hopelessness and negative feelings
  • 17.
    Health systems factors ‱Short consultations ‱ Poor health services ‱ Interventions for improving it ‱ Overworked health care providers ‱ Poor medication distribution systems ‱ Inadequate training for health care providers ‱ Lack of incentives and feedback on performance Lack of knowledge on adherence and of effective ‱ Weak capacity of the system to educate patients and provide follow-up ‱ Inability to establish community support and self-management capacity
  • 18.
    strategies to ImproveMed. Adherence ‱ The SIMPLE approach ‱ S – Simplify the regimen ‱ I – Impart knowledge ‱ M– Modify patient beliefs and behavior ‱ P – Provide communication and trust ‱ L – Leave the bias ‱ E – Evaluate adherence
  • 19.
    S—Simplify the Regimen ‱Encourage use of adherence aids. ‱ Investigate customized packaging for patients ‱ Adjust timing, frequency, amount, and dosage ‱ Match regimen to patient’s activities of daily living ‱ Consider changing the situation vs. changing the patient ‱ Avoid prescribing medications with special requirements ‱ Recommend taking all medications at the same time of day
  • 20.
    I—Impart Knowledge ‱ Adviseon how to cope with medication costs ‱ Focus on patient-provider shared decision making ‱ Involve patient’s family or caregiver if appropriate ‱ Keep the team informed (physicians, nurses, pharmacists) ‱ Provide all prescription instructions clearly in writing and verbally ‱ Reinforce all discussions often, especially for low-literacy patients ‱ Suggest additional information from Internet for interested patients
  • 21.
    M—Modify Patient Beliefsand Behavior ‱ Address fears and concerns ‱ Provide rewards for adherence ‱ Empower patients to self-manage their condition ‱ Ask patients about the consequences of not taking their medications ‱ Have patients restate the positive benefits of taking their medications ‱ Ensure that patients understand their risks if they don’t take their medications
  • 22.
    P—Provide Communication andTrust ‱ Use plain language ‱ Practice active listening ‱ Provide emotional support ‱ Improve interviewing skills ‱ Elicit patient’s input in treatment decisions
  • 23.
    L—Leave the Bias ‱Develop patient-centered communication style ‱ Acknowledge biases in medical decision making ‱ Understand health literacy and how it affects outcomes ‱ Address dissonance of patient-provider, race-ethnicity, and language ‱ Examine self-efficacy regarding care of racial, ethnic, and social minority populations
  • 24.
    E—Evaluating Adherence ‱ Self-report ‱Ask about adherence behavior at every visit ‱ Periodically review patient’s medication containers, noting renewal dates ‱ Use biochemical tests—measure serum or urine medication levels as needed ‱ Use medication adherence scales— e.g. ‱ Morisky-8 (MMAS-8), Medication Possession Ratio (MPR), ‱ Proportion of Days Covered (PDC)
  • 25.
    MEASURING ADHERENCE ‱ Thereare several ways to measure medication adherence. ‱ 1.Medication event monitoring systems (MEMS):These are the most accurate method of measuring adherence because they record the date and time the medication bottle was opened through microprocessor technology embedded in the cap.
  • 26.
    Advantages with microprocessor: ‱1. erroneous/not faith/falls., because patient may remove more than one dose ‱ 2.Very expensive & different devices are needed for each medication ‱ 3.Therefore it is an impractical way to determine adherence in clinical practice.
  • 27.
    ‱ 2.Patient self-reportsis easiest method when adherence is being assessed, open-ended questions should be asked. Instead of asking, “Are you taking your medications?” the HCP should phrase the question along the lines of, “How many times in the past week (month) have you skipped your medications?
  • 28.
    ‱ Pill counts ‱4.Pharmacy databases or refill rates, and ‱ 5.Blood levels which also are employed in research, are more feasible options for clinical practice ‱ 6.Morisky’s Medication Adherence Scale (MMAS) It was designed to distinguish poorly adherent patients from those with medium to-high adherence to their antihypertensive regimen
  • 29.
    ‱ MMAS consistsof questions addressing multiple reasons for non-adherence.. e.g., because regimen complexity can lead to noncompliance. The scale contains a question assessing whether the patient feels hassled (trouble/Tense) about his or her regimen
  • 30.
    ‱ Since patientstend to give their HCPs positive answers to please them, the questions in Morisky’s study were phrased to avoid this bias. ‱ Each question measures a specific medication taking behavior rather than adherence or compliance behavior.
  • 32.
    What patients cando to improve your adherence: ‱ Make a schedule ‱ Put them in a place that’s easy for you to remember ‱ Include in your daily routine (meal, shower, brush teeth) ‱ Keep a current list of your medications ‱ Set alarms (there’s an app for that) ‱ Use re-fill reminders and auto-fill options at your pharmacy ‱ Choose ONE pharmacy, instead of using multiple pharmacies ‱ Learn more about your medications
  • 33.
    Things you shouldknow about your medications: ‱ Name of medication and what it’s being used for ‱ How long you will be taking the medication ‱ How you should take the medication, including how many times a day and how often ‱ Should you be avoiding any foods, medications, or activities while on this medication? ‱ Side effects to look for and what to do if they happen ‱ Where to store your medications
  • 34.
    What can yourpharmacist do to help? ‱ Inform you about your medications ‱ What your medication is used for ‱ What to expect from using medication ‱ When will it start to work ‱ Will you notice any changes? ‱ Side effects to watch out for ‱ Answer any of your medication questions
  • 35.
    What can yourpharmacist do to help? ‱ Recommend ways to help you remember to take medications Pill box Bubble packs Apps
  • 36.
    What can yourpharmacist do to help? ‱ Fit medications into your schedule ‱ Come up with a schedule, using your daily routines ‱ Consider a medication that may work for a longer period of time ‱ Recommend storage options for medications when traveling ‱ Cost ‱ Cost savings/ discount programs ‱ Look for a similar medication that may cost less ‱ Avoid side effects ‱ Prevent diseases from getting worse
  • 37.
    What can yourpharmacist do to help? ‱ Medication Therapy Management (MTM) ‱ Appointment with your pharmacist ‱ Bring in all medications and over the counter products (vitamins/herbals) ‱ Pharmacist reviews all of your medications ‱ Interactions ‱ Side effects ‱ Cost savings ‱ Adherence and compliance ‱ Increase your knowledge of your medications ‱ Answer questions
  • 38.
    Always remember
 ‱ Non-adherenceand non-compliance is common ‱ You can have an impact in your health ‱ The reasons people don’t take medications are different for each person ‱ Be honest and open with your pharmacists and doctors ‱ Pharmacists want to help you overcome barriers to adherence and compliance

Editor's Notes

  • #11 A common example I hear from patients is them taking their medication every other day instead of every day in order to save money, but as you can see from the graph 50% adherence almost doubles medical spending.