Medication adherence is essential for achieving positive therapeutic outcomes, especially in chronic diseases. Non-adherence has many causes like patients not believing treatment is necessary, complex regimens, or poor communication with providers. Pharmacists can play an important role in improving adherence through patient education, simplifying dosing, minimizing side effects, reminder calls/texts, and identifying individual barriers. Proper adherence monitoring is also important, as it allows interventions when non-adherence is detected. Both direct methods like biological fluid testing and indirect methods like pill counting can assess adherence, though indirect methods are less expensive.