Gases & Vapors
Definition, role of gases in our body, focus on
Oxygen, CO2 Inorganic anesthetics: Definition,
Nitrous oxide Respiratory Stimulant: Definition,
Ammonia solution, spirit of ammonia
Phr. Kabin Maleku
Composition of the Air
• We breathe earth’s atmosphere composed of:
– Nitrogen (78%)
– Oxygen (21%)
– Carbon Dioxide (0.03%)
– Argon and trace gases (0.93%) • Neon, Xenon,
Krypton
• —Normal formless state of matter which at
room temperature and pressure has low
density/viscosity and readily and uniformly
distributes itself throughout any container
• Can be organic or inorganic Š
• Examples:
Role of gases
• Oxygen and
• Carbondioxide
Gas Exchange
• External respiration occurs as a function of
partial pressure differences in oxygen and
carbon dioxide between the alveoli and the
blood in the pulmonary capillaries.
• Internal respiration is gas exchange that
occurs at the level of body tissues . Similar to
external respiration, internal respiration also
occurs as simple diffusion due to a partial
pressure gradient.
Oxygen Transportation
• Oxygen is primarily transported through the
blood by erythrocytes. These cells contain a
metalloprotein called hemoglobin, which is
composed of four subunits with a ring-like
structure. Each subunit contains one atom of
iron bound to a molecule of heme. Heme
binds oxygen so that each hemoglobin
molecule can bind up to four oxygen
molecules
• Carbon dioxide is transported in blood by
three different mechanisms: as dissolved
carbon dioxide, as bicarbonate, or as
carbaminohemoglobin.
Oxygen
• Importance:
Used:
For Hypoxia and anoxia
Carbon monooxide poisoning
Medical oxygen
• Oxygen contains not less than 99.5% V/V of
oxygen.
• It is produced by a purification process
followed by a cryodistillation of the ambient
air.
• Assay: ≥ 99.5% V/V oxygen
• Impurities: CO (≤ 5 ppm V/V ) , CO2(≤ 300 ppm
V/V), H2O (≤ 67 ppm V/V)
• Analysis:
Medical oxygen
• Assay:
• Principle: Gasometric
• Apparatus: Nitrometer
• Absorbing Agents: NH4Cl, NH4OH
• Sample of O2 is passed to absorbing solution
• NMT 1% gas is left unabsorbed in tube
Storage
• Supports Combustion
• Store under container, well ventilated place
away from health and cold
• Keep in clean and dry place
• Away from combustible material
Carbon dioxide
• Carbon Dioxide contains not less than 99.5%
V/V of CO2.in gaseous phase.
• Infrared absorption spectrophotometry
• Assay: 99.5% V/V CO2
• Impurities:
• CO, NO/NO2 , Total Sulphur, Moisture
•
Medicinal Gases and Vapours

Medicinal Gases and Vapours

  • 1.
    Gases & Vapors Definition,role of gases in our body, focus on Oxygen, CO2 Inorganic anesthetics: Definition, Nitrous oxide Respiratory Stimulant: Definition, Ammonia solution, spirit of ammonia Phr. Kabin Maleku
  • 2.
    Composition of theAir • We breathe earth’s atmosphere composed of: – Nitrogen (78%) – Oxygen (21%) – Carbon Dioxide (0.03%) – Argon and trace gases (0.93%) • Neon, Xenon, Krypton
  • 3.
    • —Normal formlessstate of matter which at room temperature and pressure has low density/viscosity and readily and uniformly distributes itself throughout any container • Can be organic or inorganic Š • Examples:
  • 4.
    Role of gases •Oxygen and • Carbondioxide
  • 5.
    Gas Exchange • Externalrespiration occurs as a function of partial pressure differences in oxygen and carbon dioxide between the alveoli and the blood in the pulmonary capillaries. • Internal respiration is gas exchange that occurs at the level of body tissues . Similar to external respiration, internal respiration also occurs as simple diffusion due to a partial pressure gradient.
  • 10.
    Oxygen Transportation • Oxygenis primarily transported through the blood by erythrocytes. These cells contain a metalloprotein called hemoglobin, which is composed of four subunits with a ring-like structure. Each subunit contains one atom of iron bound to a molecule of heme. Heme binds oxygen so that each hemoglobin molecule can bind up to four oxygen molecules
  • 12.
    • Carbon dioxideis transported in blood by three different mechanisms: as dissolved carbon dioxide, as bicarbonate, or as carbaminohemoglobin.
  • 14.
    Oxygen • Importance: Used: For Hypoxiaand anoxia Carbon monooxide poisoning
  • 15.
    Medical oxygen • Oxygencontains not less than 99.5% V/V of oxygen. • It is produced by a purification process followed by a cryodistillation of the ambient air. • Assay: ≥ 99.5% V/V oxygen • Impurities: CO (≤ 5 ppm V/V ) , CO2(≤ 300 ppm V/V), H2O (≤ 67 ppm V/V) • Analysis:
  • 16.
    Medical oxygen • Assay: •Principle: Gasometric • Apparatus: Nitrometer • Absorbing Agents: NH4Cl, NH4OH • Sample of O2 is passed to absorbing solution • NMT 1% gas is left unabsorbed in tube
  • 17.
    Storage • Supports Combustion •Store under container, well ventilated place away from health and cold • Keep in clean and dry place • Away from combustible material
  • 18.
    Carbon dioxide • CarbonDioxide contains not less than 99.5% V/V of CO2.in gaseous phase. • Infrared absorption spectrophotometry • Assay: 99.5% V/V CO2 • Impurities: • CO, NO/NO2 , Total Sulphur, Moisture •