Migrating large databases at Facebook from InnoDB to MyRocks and HBase to MyRocks resulted in significant space savings of 2-4x and improved write performance by up to 10x. Various techniques were used for the migrations such as creating new MyRocks instances without downtime, loading data efficiently, testing on shadow instances, and promoting MyRocks instances as masters. Ongoing work involves optimizations like direct I/O, dictionary compression, parallel compaction, and dynamic configuration changes to further improve performance and efficiency.