The document summarizes the key differences between JUnit 4 and JUnit 5 (alpha). Some of the main changes in JUnit 5 include updated annotations like @Test, support for lambda-based assertions using Hamcrest matchers, assumptions and exception testing capabilities, and support for nested and parameterized tests. JUnit 5 also overhauls extension mechanisms and introduces extension points for customization. While still in development, JUnit 5 is moving to an API based on extensions and customization points rather than the runner approach used in JUnit 4.