The talk by John SJ Anderson highlights the evolution of Perl 5 from version 5.6 in 2001 to 5.24 in 2016, emphasizing the introduction of a regular release cycle that rejuvenated the language. Key improvements discussed include enhanced Unicode support, new language features like 'defined-or' and subroutine signatures, and modern tools for managing Perl installations and modules. Anderson aims to bridge the gap between modern Perl practices and programmers who may feel lost in the advancements since Perl's earlier versions.