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Multi enzyme complex
by:- Shagufta
Uploaded By: Abdul Qahar Buneri
(The Great)
AWKUM (Buner Campus)
1.Acyl transfer step
•
O
•
• CH3-C-S-COA +

HS-CYS
ACP
HS-PN

ACETYL

TRANSFERASE

COA-SH

O
CH3-C-S—CYS
ACP
HS-PN
2.MALONYL TRANSFER STEP
O

CH3 — C — S— CYS
ACP
HS — PN
+
COO —CH2 —C —S —COA
ACP MALOYNYL

SH-COA

TRANSFERASE
O

CH3-C-S-CYS
ACP
O
COO-CH2-C-S-PN
3.Condensation Step
O

CH3-C-S-CYS
O
COO-CH2-C-S-Pn
keto acyl
transferase

ACP

H+
CO2

O

HS-CYS
O

CH3-C-CH2-C-S-Pn

ACP
4.Keto reducton step
HS-CYS

O

O

ACP

CH3-C-CH2-C-S-Pn
NADH+H+
keto acyl Acp
reductase
NADP+

OH

HS-CYS
O

CH3-C-CH2-C-S-Pn

ACP
5.Condensation step
HS-CYS

OH

O

ACP

CH3-C-CH2-C-S-Pn
Hydroxacyl
Acp reductase

H2O

HS-CYS
O
CH3-CH=CH-C-S-Pn

ACP
6.Saturation
HS-CYS
O

ACP

CH3-CH=CH-C-S-Pn
enoyl Acp
reductase

NADPH+H+
NADP+
HS-CYS
O

CH3-CH2-C-S-Pn

ACP
7.The Transfer Step
HS-CYS
O

ACP

CH3-CH2-C-S-Pn
Non Enzymatic
step
O
CH3-CH2-C-S-CYS
ACP
HS-Pn
8.Clevage
CH3-CH2-C-S-CYS

ACP
O
HS-Pn
Hydrolytic
Enzyme

H2O

HS-CYS

HS-CYS
ACP

HS-Pn
CH3

+

ACP
O
C-S-Pn
Multi enzyme complex

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