This document provides instructions for upgrading from MySQL 5.0 to MySQL 5.6. It recommends making a complete backup before performing a manual upgrade which involves shutting down the existing server, removing old packages, installing new packages from Oracle, and running mysql_upgrade. Important details on incompatible changes between versions can be found in the MySQL manual. The second section provides step-by-step instructions for installing MySQL 5.6 RPM packages and restarting the service, along with notes on resolving errors.