Download as PDF, PPTX
![Magnetically-triggered drug release system. Schematics of nanoparticles, molecular machines, assembly and remote-
controlled drug release. The particles and machines are not drawn to scale (reproduced with permission from [142],
Copyright 2010, American Chemical Society).
Druge release + Hyperthermia
Nanoparticle in Drug Delivery System](https://image.slidesharecdn.com/nanoparticleindrugdeliverysystem-180918064142/75/Nanoparticle-in-drug-delivery-system-29-2048.jpg)
Uploaded bykeyhan *
Nanoparticle in drug delivery system
This document discusses the use of nanoparticles in drug delivery systems. Nanoparticles can be used to more precisely control the release of drugs in the body over time compared to traditional drug dosing. Magnetic nanoparticles are particularly useful as they can be guided to specific target sites in the body using external magnetic fields. The document outlines various methods for synthesizing magnetic nanoparticles and functionalizing them for drug delivery applications. Characterization techniques are also discussed for analyzing the nanoparticles. The document concludes that magnetic nanoparticles have the potential to improve drug targeting and control drug release while maintaining low toxicity.
In this document
Powered by AI
Introduction to NDDS, focusing on nanoparticles as a targeted drug delivery method.
Utilization of magnetic nanoparticles in various medical applications, including drug delivery.
Details on magnetic nanoparticle properties: size (3-30 nm), water solubility (e.g., Dextran, Kitosan).
Methods of synthesis: coprecipitation, reverse microemulsion, polyol, thermal decomposition.
Key design parameters: biocompatibility, size, stability, and methods for functionalizing nanoparticles.
Techniques for analyzing nanoparticles: XRD, DLS, various spectroscopic methods.
Strategies for targeted delivery using nanoparticles, including passive and active targeting.
Role of magnetic nanoparticles in drug delivery, including enzyme responsiveness and cancer therapy.
Magnetic-assisted transfection and controlled release methods, emphasizing novel delivery systems.
Summarizes the therapeutic potential of magnetic nanoparticles in drug distribution and control.
More Related Content
Similar to Nanoparticle in drug delivery system
Nanoparticle in drug delivery system
- 1. Nanoparticle in DrugDelivery System (NDDS) By: Hashem Ghezelsofla
- 2. 2 Drug delivery systems Nanoparticlein Drug Delivery System
- 3. 3 Drug levels inthe blood with (a) traditional drug dosing and (b) controlled-delivery dosing Advantages of targeted drug delivery system Nanoparticle in Drug Delivery System
- 4. Nanoparticles as adrug delivery system Nanoparticle in Drug Delivery System
- 5. Magnetic DrugTargeting (MDT) Magnetic Targeted Carriers (MTC) Nanoparticle in Drug Delivery System
- 6. application of magnetic nanoparticles in medicine Diagnosis Invitro Bio-Sensing Cell separation Transfection Biological separation Enzyme stabilizationInvivo MRI Therapy Drugdelivery Hyperthermia Magnetic nanoparticles are used for a wide range of clinical applications Nanoparticle in Drug Delivery System
- 7. Nanoparticle in DrugDelivery System
- 8. Magnetic nanoparticles indrug delivery Nanoparticle in Drug Delivery System Particle size 3-30 nm Particle size distribution 10-20% Dissolved in water Dextran Kitosan
- 9. Magnetic nanoparticles inmedical applications Nanoparticle in Drug Delivery System
- 10. Processes of magneticparticles preparation for drug delivery Nanoparticle in Drug Delivery System
- 11. Methods for MagneticNanoparticles (MNPs) Synthesis Reduction Copercipitation Reverse microemulsion polyol Thermal Decomposition Sonochemical Hydrothermal Microwave Nanoparticle in Drug Delivery System
- 12. Copercipitation method Nanoparticle inDrug Delivery System
- 13. Reverse microemulsion synthesismethod Nanoparticle in Drug Delivery System
- 14. Polyol synthesis method Nanoparticlein Drug Delivery System
- 15. Thermal decomposition method Nanoparticlein Drug Delivery System
- 16. Design of nanoparticlesfor bioapplications Biocompatibility Size (10- 20 nm) Secretion (PEG) Stable Nanoparticle in Drug Delivery System
- 17. Methods for MagneticNanoparticle Synthesis and Functionalization Insitu Post synthetic coating Direct exchange Ligand exchange Nanoparticle in Drug Delivery System
- 18. Characterization techniques for nanomaterials (XRD) X-ray diffraction DLS(dynamic light scattering) zeta potential VSM(vibrating-sample magnetometer) Squid magnetometer IR Spectroscopy TEM (Transmission electron microscopy) TGA (Themal Gravimetry Analysis) XPS (X-ray photoelectron spectroscopy) Mössbauer spectroscopy Nanoparticle in Drug Delivery System
- 19. XRD (X-ray diffraction) DLS(dynamic light scattering) Zeta potential Nanoparticle in Drug Delivery System
- 20. VSM (vibrating-sample magnetometer) Squidmagnetometer Nanoparticle in Drug Delivery System
- 21. TGA(Themal Gravimetry Analysis)XPS (X-ray photoelectron spectroscopy) Mössbauer spectroscopy Nanoparticle in Drug Delivery System
- 22. Targeted Drug Delivery Passive Targeting EPR(enhanced permeability and retention) Physicalfeatures Nano carrier size linkage Localised delivery Active Targeting Antibodies Ligands Aptamers Nanoparticle in Drug Delivery System
- 23. Nanoparticle–biomolecule conjugate Nucleicacids antibody Peptides Proteins Phospholipides Carbohydrates Hormons aptamer Nanoparticle in Drug Delivery System
- 24. Targeted drug deliveryagents Nanoparticle in Drug Delivery System
- 25. Applications of MagneticNanoparticles in Targeted Drug Delivery System Magnetic nanoparticles as the nucleus for delivering targeted drugs A High Field Gradient Magnet for Magnetic Drug Targeting Enzyme-responsive nanoparticles for drug release change in thephysiological condition (PH- Temperature) MRI Nanoparticle in Drug Delivery System
- 26. Applications of MagneticNanoparticles in Targeted Drug Delivery System Hyperthermia directed specifically to cancer cells through the use of magnetic nanoparticles heated with alternating magnetic fields has been used as a novel cancer therapy Nanoparticle in Drug Delivery System
- 27. Nanoparticle in DrugDelivery System
- 28. Magnetic Assisted Transfection Nanoparticlein Drug Delivery System
- 29. Magnetically-triggered drug releasesystem. Schematics of nanoparticles, molecular machines, assembly and remote- controlled drug release. The particles and machines are not drawn to scale (reproduced with permission from [142], Copyright 2010, American Chemical Society). Druge release + Hyperthermia Nanoparticle in Drug Delivery System
- 30. Conclusions 30 • Improve themedicinal and therapeutic properties • Transfer the drug to a specified amount • Transferring medicine to a specific place in the body • The effects of medications and the distribution of medicine in the body The ability to control the movement of magnetic particles in the body is possible using an external magnetic field. Due to their low toxicity, these particles are used in various branches, including medicine, MRI and hyperthermia and gene therapy and DNA transducer. Nanoparticle in Drug Delivery System