TypeScript is a typed superset of JavaScript that optionally adds static typing to JavaScript code for improved maintainability. It supports features like classes, interfaces, and modules and compiles to plain JavaScript. The presentation introduced TypeScript's key features and syntax, showed how to configure TypeScript projects and add type annotations, and demonstrated building a simple end-to-end application with TypeScript. TypeScript is an open source language maintained by Microsoft that brings the benefits of static typing to JavaScript without losing JavaScript's dynamics.