Vasu Balla of Pythian presented on best practices for upgrading an Oracle E-Business Suite database to Oracle Database 12c. The typical upgrade process involves installing the 12c Oracle home, upgrading the database using DBUA or CLI, and completing post-upgrade steps. Key best practices include ensuring initialization parameters and patches are configured properly, using AWR to identify performance issues and bad execution plans post-upgrade, and preserving good plans using SQL plan baselines. Regular statistics gathering and tuning of database settings also helps optimize performance.