Organ transplantation

ORGAN TRANSPLANT
MADE BY : RASHMI KUMARI
BIOSCIENCE DEPARTMENT

WHAT IS ORGANTRANSPLANT?
 The moving of an organ from one body to
another, for the purpose of replacing the
recipient's damaged or failing organ with a
working one from the donor site.
 Organ donors can be living or deceased.

TYPES OFTRANSPLANTS:
Autograft
Allograft
Isograft
Xenograft and Xenotransplantion
Split transplants
Domino transplants

Autograft
A transplant of tissue from one to oneself.
Sometimes this is done with surplus tissue, or tissue
that can regenerate, or tissues more desperately
needed elsewhere.
 Sometimes an autograft is done to remove the
tissue and then treat it or the person, before
returning it.
>skin grafts, vein extraction
>storing blood in advance of surgery

Allograft
An allograft is a transplanted organ or tissue
from a genetically non-identical member of the
same species. Most human tissue and organ
transplants are allografts.

Isograft
A subset of allografts in which
organs or tissues are transplanted
from a donor to a genetically
identical recipient (such as an
identical twin).
Isografts are differentiated from
other types of transplants because
while they are anatomically
identical to allografts, they don't
trigger an immune response.

Xenograft and Xenotransplantion
A transplant of organs or tissue from one
species to another. Xenotransplantion is often an
extremely dangerous type of transplant.
Examples include porcine heart valves, which
are quite common and successful, a baboon-to-
human heart (failed), and piscine-primate (fish
to non-human primate) islet (i.e. pancreatic or
insular tissue), the latter's research study
directed for potential human use if successful.

Split transplants
Sometimes a deceased-donor organ, usually a
liver, may be divided between two recipients,
especially an adult and a child.
This is not usually a preferred option
because the transplantation of a whole organ
is more successful.

Domino transplants
This operation is usually performed on patients with cystic fibrosis
because both lungs need to be replaced and it is a technically easier
operation to replace the heart and lungs at the same time.
As the recipient's native heart is usually healthy, it can be transplanted
into someone else needing a heart transplant.
That term is also used for a special form of liver transplant in which
the recipient suffers from familial amyloidotic polyneuropathy, a
disease where the liver slowly produces a protein that damages other
organs. This patient's liver can be transplanted into an older patient
who is likely to die from other causes before a problem arises.

Major organs and tissues transplanted
Thoracic organs
 Heart (Deceased-donor only)
 Lung (Deceased-donor and Living-Donor)
 Heart/Lung (Deceased-donor and Domino transplant)
Abdominal organs
 Kidney (Deceased-donor and Living-Donor)
 Liver (Deceased-donor and Living-Donor)
 Pancreas (Deceased-donor only)
 Intestine (Deceased-donor and Living-Donor)
 Stomach (Deceased-donor only)

Tissues, cells, fluids
Hand (Deceased-donor only)
Cornea (Deceased-donor only)
Skin including Face replant (autograft) and
Face transplant (extremely rare)
Islets of Langerhans (Pancreas Islet Cells) (Deceased-
donor and Living-Donor)
Bone marrow/Adult stem cell (Living-Donor and
Autograft)
Blood transfusion/Blood Parts Transfusion (Living-
Donor and Autograft)
Blood vessels (Autograft and Deceased-Donor)
Heart valve (Deceased-Donor, Living-Donor and
Xenograft[Porcine/bovine])
Bone (Deceased-Donor and Living-Donor)

Living or deceased
In living donors, the donor remains alive
and donates a renewable tissue, cell, or fluid
(e.g. blood, skin); or donates an organ or
part of an organ in which the remaining
organ can regenerate or take on the
workload of the rest of the organ (primarily
single kidney donation, partial donation of
liver, small bowel).

Deceased (formerly cadaveric) are
donors who have been declared brain-dead
and whose organs are kept viable by
ventilators or other mechanical mechanisms
until they can be excised for transplantation.
There is increasing use of Donation after
Cardiac Death - DCD- Donors (formerly
non-heart beating donors) to increase the
potential pool of donors as demand for
transplants continues to grow.

Timeline of successful transpants
 1905: First successful cornea transplant by Eduard Zirm
 1954: First successful kidney transplant by Joseph Murray (Boston, U.S.A.)
 1966: First successful pancreas transplant by Richard Lillehei and William Kelly (Minnesota,
U.S.A.)
 1967: First successful liver transplant by Thomas Starzl (Denver, U.S.A.)
 1967: First successful heart transplant by Christiaan Barnard (CapeTown, South Africa)
 1970: First successful monkey head transplant by RobertWhite (Cleveland, U.S.A.)
 1981: First successful heart/lung transplant by Bruce Reitz (Stanford, U.S.A.)
 1983: First successful lung lobe transplant by Joel Cooper (Toronto, Canada)
 1986: First successful double-lung transplant (Ann Harrison) by Joel Cooper (Toronto, Canada)
 1987: First successful whole lung transplant by Joel Cooper (St. Louis, U.S.A.)
 1995: First successful laparoscopic live-donor nephrectomy by Lloyd Ratner and Louis Kavoussi
(Baltimore, U.S.A.)
 1998: First successful live-donor partial pancreas transplant by David Sutherland (Minnesota,
U.S.A.)
 1998: First successful hand transplant (France)
 2005: First successful partial face transplant (France)
 2006: First successful penis transplant (China)
 2014: First successful uterine transplant resulting in live birth (Sweden)

What Is The Maximum Time Span Between Recovering
Organs/Tissues andTransplantation?
Lung (4-6 hours)
Heart (4-6 hours)
Liver (24 hours)
Pancreas (24 hours)
Kidney (72 hours)
Corneas (14 days)
Bone (5 years)
Skin (5 years)
Heart valves (10 years).

How are organs allocated?
ABO blood type
Medical urgency
Time on the waiting list
Geographic location

Transplant Rejection
Transplant rejection
◦ Hyperacute
◦ Occurs minutes to hours after
transplantation
◦ No treatment (organ must be
removed)
◦ Acute
◦ Occurs days (one week) to months
after transplantation
◦ T- cytotoxic lymphocytes attack the
transplanted organ
◦ Chronic
◦ Occurs over months to years
◦ Most common in lung transplants
Some Common Signs &
Symptoms
Pain at the site of the
transplant
Feeling ill
Flu-like symptoms
Fever
Weight change
Swelling
Decreased urine output

ImmunosuppressiveTherapy
Triple therapy (all PO/IV)
◦ Cyclosporine
◦ Prevent a cell-mediated attack (helper T-cells) against the organ
◦ Corticosteriod: prednisone-methylprednisolone (Solu-Medrol)
◦ Suppress inflammatory response
◦ Cytotoxic drug: mycophenolate mefetil (CellCept) or
cyclophosphamide (Cytoxan)
◦ Suppress immune response by inhibiting proliferation of T and B cells
Monoclonal Antibodies: muromonab-CD3
◦ Used for preventing and treating acute rejection episodes
Polyclonal Antibodies:Atgam
◦ Used as induction therapy or to treat acute rejection

ImmunosuppressiveTherapy: Side
Effects
Nephrotoxicity
Increased risk of infection
Lymphoma
Hepatotoxicity
Neutropenia
Thrombocytopenia
Diarrhea/nausea/vomiting

Living related donors
Living related donors donate to family members
or friends in whom they have an emotional
investment. The risk of surgery is offset by the
psychological benefit of not losing someone related
to them, or not seeing them suffer the ill effects of
waiting on a list.
Paired-exchange

Good Samaritan
 "Good Samaritan" or "altruistic"
donation is giving a donation to someone
not well-known to the donor. Some
people choose to do this out of a need to
donate.

Forced donation
 There have been various accusations
that certain authorities are harvesting
organs from those the authorities deem
undesirable, such as prison populations.

Allocation of donated organs
The overwhelming majority of deceased-donor
organs in India are allocated by National Organ and
Tissue Transplant Organization (NOTTO).
It Functions as apex centre for All India activities of
coordination and networking for procurement and
distribution of Organs and Tissues and registry of
Organs and Tissues Donation and Transplantation in
the country. The following activities would be
undertaken to facilitate Organ Transplantation in the
safest way in shortest possible time

Ethical Issues Regarding Procurement of Organs and
Tissues.
Buying and Selling Human Organs and
Tissues
Media Publicity
Types of Consent (Voluntary or Expressed,
Family, Presumed, Required Request, Routine
Inquiry).

Why Donate?

Each year, thousands of people die while waiting for a transplant, because no suitable
donor can be found for them.The need for organ donors has never been greater.
Did you know In India every year nearly:
500,000 people die because of non-availability of organs 200,000 people die of liver● ●
disease
50,000 people die from heart disease 150,000 people await a kidney transplant but● ●
only 5,000 get one 1,000,000 lakh people suffer from corneal blindness and await●
transplant
Nationally, with a population of 1.2 billion people, the statistic stands at 0.34 persons as
organ donors per million population (PMP).This is an incredibly small and insignificant
number compared to the statistics around the world.
It is difficult to think about organ donation when you have just lost a loved one;
however organ donation is a generous and worthwhile decision that can save many lives.
By donating, each person can save the lives of upto 7 individuals by way of organ donation
and enhance the lives of over 50 people by way of tissue donation.

Organ transplantation

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