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Otoacoustic emissions(physiogical 
measures of auditory sensitivity) 
Otoacustic emissions are acoustic singnals emitted from the cochlea to the middle ear & the external 
ear canal where they are recorded.They are generated by active mechanical contraction of outer 
hair cells, spontaneously or in response to sound. 
There ar four types of OAEs:spontaneous OAEs(SOAE) 
Transient evoked OAE(TOAE) 
Distortion product OAE(DPOAE) 
Stimulus frequency OAE(SFOAE) 
All four are recorded with a sensitive ,low noise recording microphone that is placed in the sealed 
external ear canal. 
When OAE are evoked ,the sealed probe include a sound delivery to external ear canal in addition to 
the recording microphone. 
Middle ear &inner ear disease might reduce or block acoustic transmission of OAE from the cochlea 
to the recording microphone. So tympanometry is done before OAE recording. 
Transient-evoked emissions 
In human a delay between stimulus offset & onset of the evoked emission varies between 4ms for 
high frenquencies,& 20ms for low frequencies. 
The TEOAE are typically presented as an amplitude/time plot of the acoustic waveform recorded 
from ear canal. 
TEOAEs greater than 20db sound pressure level(SPL) can be recorded from newborn,while response 
from children & adult range between 10 &15dbSPL. 
TEOAEs can be altered in the presence of contralateral stimulation.Typically the effect of 
contralateral stimulation is an attenuation of the response which is attributed to efferent effects on 
the cochlea.The attenuation is most evident beginning 8ms after stimulus onset suggesting a 
brainstem mediated effect. 
Distortion product emissions: 
DPOAEs are generated in the cochlea in response to two simultaneous pure tone stimuli. The 
primary tones (f1&f2) are separated in frequency within 1/3rd octave(typically f2= f1×1.2)& the 
distortion product is then typically at a frequency of 2f1-f2.
Although DPOAEs are reliably recorded in presence from all normal human,their magnitude is very 
small 5-15dbSPL ,approximately 60-70db below the level of the stimuli used to evoke them.DPOAEs 
attributed to nonlinearity of motion of the outer hair cells particularly at low stimuli levels. 
PDOAEs are typically presented in a magnitude/frequency plot in which frequency is determined by 
f2 at low levelor the geometric mean of f1&f2 &magnitude is determined for DPOAEs at the 2f1-f2 
frequency bin.Such plot is called a DB-gram.& It has been shown to correlate with functional 
integrity of the cochlea. 
Otoacoustic emissions(K.j.Lee) 
Otoacustic emission(OAEs) are acoustic signals generated by cochlear OHC & transmitted out 
through the middle ear to the ear canal where they can be recorded by a sensitive microphone in a 
quite ,but not usually sound treated environment. 
As a measure of OHC function,OAEs can be used to screen hearing,to estimate cochlear sensitivity by 
frequency,& to differentiate between sensory & neural hearing loss. 
They cab be used neonates &comatose patients. 
Two types of EOAEs are in common clinical use,Transient otoacoustic emission(TOAEs) &distortion 
product otoacoustic emission(DPOAEs).Sustained frequency otoacoustic emission(SFOAMs) have no 
clinical use. 
Characteristic of all OAEs 
1) Can be detected as acoustic energy within external auditory canal. 
2) Pathway of energy transfer is OHC>basilar membrane>cochlear fluids> oval 
window>ossicles> Tympanic membrane,which act as a loud speaker to external canal. 
3) OAEs are an epiphenomena, that is , not a process of hearing but a by product of it. 
4) Efficient, objective ,noninvasive window into cochlear function. 
5) Present OAEs indicate intact OHC function but absent OAEs do not necessarily indicate OHC 
malfunction, unless normal middle ear status is confirmed. 
Three types of OAEs recorded clinically 
SOAEs: about 35-60% of normal hearing individual have SOAEs that is generated with no external 
stimulus. 
TOAEs: occur in response to transient signal such as click.TOAEs are absent in cochlear lesion, but 
present in purely neural lesion. 
1)Low level responses below 30dbSPL must be measure in a quite environment.
2) A sign that the cochlea has either normal function through the OHCs or has no more 30-40dbHL 
sensorineural hearing impairment. 
3) TOAEs can be analyzed by octave band for presence or absence of cochlear response across the 
frequence range but only provides a present or absent response for whether cochlear hearing is 
better or worse than the 30-40db range at each octave band up through 4000Hz. 
DPOAEs: DPOAEs occur in response to two simultaneous pure tones of different frequency(f1&f2). 
In response to f1 &f2 stimuli,the healthy cochlea then produces several distortion products (DPs) 
at frequencies different from the stimuli.The most prominent DP is usually at the frequency 2f2-f1. 
1)A DPOAE is a single tone evoked by two simultaneously presented pure tones. 
2)Stimulation levels are typically 55-65 SPL but intensity functions may be tested . 
3)usually easiest to obtain a DP from human cochlea when the stimulus or primary frequencies f1 
&f2 are separated by ratio of 1:1.2 .for example, 2000 &24000Hz. 
4) by using different combination of primary tones different DP frequencies can be generated ,there 
by allowing objective assessment of a large portion of the basilar membrane 
5)Of the several interaction of the stimulus tones ,the interaction 2f1 –f2 (or cubic difference tone), 
usually produces the most detectable DP whose frequency is lower than either of the stimulus 
frequencies. 
6)Reflects cochlear status nearer f2 as opposed to f1 or the DP. 
7) DPOAEs can be obtained in persons with more OHC loss & in response to higher frequency stimuli 
than can TOAEs. 
Clinical applications of both TOAEs & SPOAEs 
1)Neonatal ear specific hearing screening. 
2) part of test battery for auditory neuropathy,a rare condition in which there is sensorineural 
hearing loss ,abnormal ABR, absent acoustic reflexes & poor recognization ability than expected 
based on pure tone audiogram but OAEs are present. 
3) useful in patient who are difficult to test. 
4)Differentiating between cochlear & eight nerve lesion in sensorineural hearing loss( including 
idiopathic sudden hearing loss & candidacy for cochlear implant).Because OAEs are preneural events 
,absent EOAEs in losses 40db or greater point to the cochlea as a site of lesion whereas present OAEs 
support an eight nerve site of lesion . 
5)Monitoring for ototoxic or exposure to high sound level;DPOAEs& TOAEs may be lost or 
diminished for high frequencies before changing in Pure Tone Audiometry.
6)In cases of suspected PHA(pseudohypoacusis), Present TOAEs assures no significant conductive 
hearing loss & no cochlear loss greater than 40db HL &probably less than 30dbHL.DPOAEs can also 
contribute objective information of possible audiometric configuration & cochlear sensitivity.

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Otoacoustic emissions (sbo 3& k.j.lee )

  • 1. Otoacoustic emissions(physiogical measures of auditory sensitivity) Otoacustic emissions are acoustic singnals emitted from the cochlea to the middle ear & the external ear canal where they are recorded.They are generated by active mechanical contraction of outer hair cells, spontaneously or in response to sound. There ar four types of OAEs:spontaneous OAEs(SOAE) Transient evoked OAE(TOAE) Distortion product OAE(DPOAE) Stimulus frequency OAE(SFOAE) All four are recorded with a sensitive ,low noise recording microphone that is placed in the sealed external ear canal. When OAE are evoked ,the sealed probe include a sound delivery to external ear canal in addition to the recording microphone. Middle ear &inner ear disease might reduce or block acoustic transmission of OAE from the cochlea to the recording microphone. So tympanometry is done before OAE recording. Transient-evoked emissions In human a delay between stimulus offset & onset of the evoked emission varies between 4ms for high frenquencies,& 20ms for low frequencies. The TEOAE are typically presented as an amplitude/time plot of the acoustic waveform recorded from ear canal. TEOAEs greater than 20db sound pressure level(SPL) can be recorded from newborn,while response from children & adult range between 10 &15dbSPL. TEOAEs can be altered in the presence of contralateral stimulation.Typically the effect of contralateral stimulation is an attenuation of the response which is attributed to efferent effects on the cochlea.The attenuation is most evident beginning 8ms after stimulus onset suggesting a brainstem mediated effect. Distortion product emissions: DPOAEs are generated in the cochlea in response to two simultaneous pure tone stimuli. The primary tones (f1&f2) are separated in frequency within 1/3rd octave(typically f2= f1×1.2)& the distortion product is then typically at a frequency of 2f1-f2.
  • 2. Although DPOAEs are reliably recorded in presence from all normal human,their magnitude is very small 5-15dbSPL ,approximately 60-70db below the level of the stimuli used to evoke them.DPOAEs attributed to nonlinearity of motion of the outer hair cells particularly at low stimuli levels. PDOAEs are typically presented in a magnitude/frequency plot in which frequency is determined by f2 at low levelor the geometric mean of f1&f2 &magnitude is determined for DPOAEs at the 2f1-f2 frequency bin.Such plot is called a DB-gram.& It has been shown to correlate with functional integrity of the cochlea. Otoacoustic emissions(K.j.Lee) Otoacustic emission(OAEs) are acoustic signals generated by cochlear OHC & transmitted out through the middle ear to the ear canal where they can be recorded by a sensitive microphone in a quite ,but not usually sound treated environment. As a measure of OHC function,OAEs can be used to screen hearing,to estimate cochlear sensitivity by frequency,& to differentiate between sensory & neural hearing loss. They cab be used neonates &comatose patients. Two types of EOAEs are in common clinical use,Transient otoacoustic emission(TOAEs) &distortion product otoacoustic emission(DPOAEs).Sustained frequency otoacoustic emission(SFOAMs) have no clinical use. Characteristic of all OAEs 1) Can be detected as acoustic energy within external auditory canal. 2) Pathway of energy transfer is OHC>basilar membrane>cochlear fluids> oval window>ossicles> Tympanic membrane,which act as a loud speaker to external canal. 3) OAEs are an epiphenomena, that is , not a process of hearing but a by product of it. 4) Efficient, objective ,noninvasive window into cochlear function. 5) Present OAEs indicate intact OHC function but absent OAEs do not necessarily indicate OHC malfunction, unless normal middle ear status is confirmed. Three types of OAEs recorded clinically SOAEs: about 35-60% of normal hearing individual have SOAEs that is generated with no external stimulus. TOAEs: occur in response to transient signal such as click.TOAEs are absent in cochlear lesion, but present in purely neural lesion. 1)Low level responses below 30dbSPL must be measure in a quite environment.
  • 3. 2) A sign that the cochlea has either normal function through the OHCs or has no more 30-40dbHL sensorineural hearing impairment. 3) TOAEs can be analyzed by octave band for presence or absence of cochlear response across the frequence range but only provides a present or absent response for whether cochlear hearing is better or worse than the 30-40db range at each octave band up through 4000Hz. DPOAEs: DPOAEs occur in response to two simultaneous pure tones of different frequency(f1&f2). In response to f1 &f2 stimuli,the healthy cochlea then produces several distortion products (DPs) at frequencies different from the stimuli.The most prominent DP is usually at the frequency 2f2-f1. 1)A DPOAE is a single tone evoked by two simultaneously presented pure tones. 2)Stimulation levels are typically 55-65 SPL but intensity functions may be tested . 3)usually easiest to obtain a DP from human cochlea when the stimulus or primary frequencies f1 &f2 are separated by ratio of 1:1.2 .for example, 2000 &24000Hz. 4) by using different combination of primary tones different DP frequencies can be generated ,there by allowing objective assessment of a large portion of the basilar membrane 5)Of the several interaction of the stimulus tones ,the interaction 2f1 –f2 (or cubic difference tone), usually produces the most detectable DP whose frequency is lower than either of the stimulus frequencies. 6)Reflects cochlear status nearer f2 as opposed to f1 or the DP. 7) DPOAEs can be obtained in persons with more OHC loss & in response to higher frequency stimuli than can TOAEs. Clinical applications of both TOAEs & SPOAEs 1)Neonatal ear specific hearing screening. 2) part of test battery for auditory neuropathy,a rare condition in which there is sensorineural hearing loss ,abnormal ABR, absent acoustic reflexes & poor recognization ability than expected based on pure tone audiogram but OAEs are present. 3) useful in patient who are difficult to test. 4)Differentiating between cochlear & eight nerve lesion in sensorineural hearing loss( including idiopathic sudden hearing loss & candidacy for cochlear implant).Because OAEs are preneural events ,absent EOAEs in losses 40db or greater point to the cochlea as a site of lesion whereas present OAEs support an eight nerve site of lesion . 5)Monitoring for ototoxic or exposure to high sound level;DPOAEs& TOAEs may be lost or diminished for high frequencies before changing in Pure Tone Audiometry.
  • 4. 6)In cases of suspected PHA(pseudohypoacusis), Present TOAEs assures no significant conductive hearing loss & no cochlear loss greater than 40db HL &probably less than 30dbHL.DPOAEs can also contribute objective information of possible audiometric configuration & cochlear sensitivity.