INTRODUCTION
1. Introduction
Definition: Painis āan unpleasant sensory and emotional
experienceā ā Associated with actual or potential tissue damage, or
described in terms of such damageā
⢠āPain is what the patient says hurtsā
* Purpose of Pain: Acute ā acts as a protective signal; Chronic ā
often becomes a maladaptive disease state .
* Epidemiology: Affects millions worldwide, with chronic pain (>3
months) leading cause of disability .
CLASSIFICATION
2. Classification
A. ByDuration (per Harrison & AMBOSS)
TYPE
Acute
Subacute
Chronic
DURATION
<1 Month
1-3
Months
>3 Months
ROLE
Protective signal of
tissue damage
Transition phase
Independent
diseases;
biopsychosocial
8.
ACUTE PAIN
⢠Injury,trauma, spasm or disease to
skin, muscle, somatic structures or
viscera;
⢠Perceived and communicated via
peripheral mechanisms (pathways)
⢠Usually associated with autonomic
response as well (tachycardia,Āblood
pressure, diaphoresis, pallor,
mydriasis (pupil dilation).
9.
CHRONIC PAIN
a.Non-malignant
⢠Painpersists beyond the
precipitating injury
⢠Rarely accompanied by autonomic
symptoms
⢠Sufferers often fail to demonstrate
objective evidence of underlying
pathology.
⢠Characterized by location-visceral,
myofascial, or neurologic causes.
10.
CHRONIC PAIN
b.Malignant
⢠Hascharacteristics of chronic
pain as well as symptoms of
acute pain (breakthrough pain).
⢠Has a definable cause, e.g.
tumour recurrence
⢠In treatment, narcotic
habituation is generally not a
concern.
CLASSIFICATION
2. Classification
B. ByMechanism (Harrison & IASP-INTERNATIONAL ASSOCIATION FOR THE STUDY OF PAIN)
Nociceptive: Tissue injury ā superficial, deep, or visceral
Neuropathic: Nerve damage ā peripheral (āburningā, ātinglingā) or central
Nociplastic: Abnormal amplification without clear tissue damage
Types of pain
Basedon Mechanism (Harrison & IASP-INTERNATIONAL ASSOCIATION FOR THE STUDY OF PAIN)
1.Nociceptive pain: Due to activation of nociceptors by tissue damage or inflammation
* somatic pain: skin,bone,muscle (sharp well-localised)
Example: Fracture, incision, arthritis
* Visceral Pain: Internal organs (dull, poorly localized, cramping)
Example: Appendicitis, gallstones, ischemia
2.Neuropathic pain: Caused by nerve damage (peripheral or central nervous system)
* Peripheral: Diabetic neuropathy, trigeminal neuralgia
*Central: Stroke, multiple sclerosis
*Descriptors*: Burning, tingling, electric-shock-like
3. Nociplastic pain: Altered pain processing without clear tissue or nerve damage
⢠Common in fibromyalgia, chronic tension headache, irritable bowel syndrome
⢠Pain is widespread, variable, and not explained by structural damage
15.
Types of pain
Basedon duration
A. By Duration (per Harrison & AMBOSS)
TYPE
Acute
Subacute
Chronic
DURATION
<1 Month
1-3
Months
>3 Months
DESCRIPTION
Sudden onset, protective
function, linked to injury
Transition between acute
and chronic
Persistent, may become a
disease in itself
Examples of Chronic Pain:
* Chronic back pain
* Osteoarthritis
* Phantom limb pain
* Post-herpetic neuralgia
16.
Types of pain
Basedon causes (ICD-11)
1. Chronic Primary Pain
* Pain is the disease itself
* Includes:
* Fibromyalgia
* Chronic widespread pain
* Non-specific low back pain
2. Chronic Secondary Pain
* Pain is a symptom of another condition
* Subtypes:
* Cancer-related pain
* Post-surgical/post-traumatic pain
* Neuropathic pain
* Visceral pain (IBD, endometriosis)
* Musculoskeletal pain (RA, OA)
Pain Assessment
Pain History
SOCRATES
SITEOF PAIN- Somatic pain-well localized
visceral pain-more diffuse(angina)
ONSET- Speed of onset and any associations
CHARACTERISTIC OF PAIN- Example: sharp,dull,burning,tingling,stabbing,crushing
RADIATION OF PAIN
ASSOCIATED SYMPTOMS
TIME/DURIATION OF PAIN
EXACERBATING FACTORS
SEVERITY OF PAIN
19.
Pain Assessment
Pain History
ā¢Other important additional questions to be asked.
⢠What is the response to past and current analgesic therapy?
⢠Any kind of diary or record about the pain?
⢠Fears they have about analgesics?
20.
Pain Assessment
Pain assessmenttools
Numeric rating scale
Verbal descriptive Scales.
Visual Analogue Scales.
McGill pain questionnaire
Factors to consider in choosing a pain scale
1. Age of patient
2. Physical condition
3. Level of consciousness
4. Mental status
5. Ability to communicate
21.
Pain Assessment
Numeric PainRating Scale
⢠Ask the patient to rate their pain intensity on a scale of 0 (no pain) to 10
(the worst pain imaginable).
⢠Some patients are unable to do this with only verbal instructions, but may
be able to look at a number scale and point to the number that describes the
intensity of pain
22.
Pain Assessment
⢠Wong-BakerFACES Pain Rating Scale
⢠Can be used with young children (sometimes as young as 3 years of age)
⢠Works well for many older children and adults as well as for those who
speak a different language
⢠Explain that each face represents a person who may have no pain, some
pain, or as much pain as imaginable. Point to the appropriate face and
say the appropriate description. e.g. āThis face hurts just a little bitā
23.
Pain Assessment
⢠Wong-BakerFACES Pain Rating Scale
⢠Ask the patient to choose the face that best matches how she or he feels or
how much they hurt.
24.
Pain Assessment
Color PainRating Scale
⢠Ask the patient to point to the area on the scale that shows their level of
pain from white (no pain) to dark red (worst possible pain).
⢠Obtain a number corresponding to the area where the patient points.
25.
Pain Assessment
Severity Assessment
ā¢McGill Pain Questionnaire
⢠Scale from 0 to 5
⢠From None to Severe Pain
⢠for children or adults who understand numerical relationships.
Pain treatment
Goals ofPain Management Therapy
1) Decreased pain
2) Decreased healthcare utilization
o Decreased āshoppingā for care
o Decreased emergency room visits
3) Improved functional status
o Increased ability to perform activities of daily living
o Return to employment
Pain treatment
Pharmacological interventions
Analgesics
1.Non opioid
ā Analgesics (Step 1 WHO Ladder)
Acetaminophen (Paracetamol)
* Adults: 500ā1,000 mg PO every 6 hours, max 4 g/day.
* Children: 15 mg/kg PO/PR q4ā6 h, max 60 mg/kg/day (max 4 g/day)
32.
Pain treatment
Pharmacological interventions
Analgesics
ā¢NSAIDs
⢠1. Ibuprofen 400ā800 mg PO every 6 hours (max 3,200 mg/day) .
⢠2. Diclofenac 50 mg PO q8 h or 75 mg PO bid (max 200 mg/day) .
⢠3. Ketorolac IV/IM 15ā30 mg q6 h (max 120 mg/day, ⤠5 days)
⢠4. Meloxicam 7.5ā15 mg PO q24 h
⢠5. Celecoxib 200 mg PO q12 h .
⢠ā ļøUse NSAIDs cautiously with renal, cardiovascular, or GI comorbidities
33.
Pain treatment
Pharmacological interventions
Analgesics
2.Weak Opioids (Step 2 WHO Ladder)
Tramadol
* Adults: 50ā100 mg PO every 4ā6 h PRN; max 400 mg/day .
* Parenteral: 50ā100 mg IV/IM q4ā6 h PRN .
Codeine combos
* Codeine + Acetaminophen: 1ā2 tablets every 4 hours PRN (e.g., 30 mg
codeine + 300 mg APAP) .
34.
Pain treatment
Pharmacological interventions
Analgesics
3.Strong Opioids (Step 3 WHO Ladder)
Morphine
* Immediate-release: 10 mg PO q4 h PRN (typical replacement for IV dose
~0.1ā0.2 mg/kg IV q4 h) .
* Modified-release: 10ā60 mg PO q12 h (dose-titrated) .
* Injectable: 10 mg/mL ampules; IV dosing as above
Oxycodone
* Controlled-release: 10 mg PO q12 h
35.
Pain treatment
Pharmacological interventions
Analgesics
3.Strong Opioids (Step 3 WHO Ladder)
Fentanyl
* Injectable: 0.35ā0.5 µg/kg IV every 30ā60 min PRN
* Transdermal patch: used when oral intake not possible; dosing per product.
Buprenorphine
* Transdermal for chronic painādosing per product guidelines .
36.
Pain treatment
Pharmacological interventions
Adjuvants
4.Adjuvants / Ancillaries
* Antidepressants (e.g., amitriptyline, nortriptyline,
SNRIs) for neuropathic pain.
* Anticonvulsants (e.g., gabapentin/pregabalin).
* Steroids, bisphosphonates, ziconotide (intrathecal) for
specific cancer pain scenarios .
37.
Pain treatment
Pharmacological interventions
5.Special Populations
* Children: Use age-appropriate preparations and weight-based dosing (e.g.,
ibuprofen 200 mg/5 mL syrup; paracetamol 120 mg/5 mL).
* Elderly / Renal/Hepatic impairment: Start lower, titrate up cautiously for
opioids and NSAIDs .
38.
Pain treatment
Choosing theAppropriate Analgesic
⢠Match the severity of pain to the strength of the analgesic i.e. strong
analgesics for severe pain.
⢠The WHO has developed 3-step model to guide analgesic choice
depending on the severity of the patientās pain.
Pain treatment
Other modalities
ā¢Nerve blocks, epidural blocks and ablative neurosurgical
procedures may be effective in pain management.
⢠Such procedures may be associated with return of pain
after a number of months so that timing of procedures may
be important.