Paper presentation ppt ICSISCON 2015

Comparative Study of Mortality as a Post Operative
Complication in Emergency Laparotomies in Diabetic and Non
Diabetic Patients
Dr. Aditya Ghatnekar PG Student
Dr. Balaji Dhaigude
Professor
Department of General Surgery
Dr. DY Patil Medical college Hospital & Research Center
Pune
1

AIMS
• To evaluate the causes of mortality as a post
operative complications in diabetic and non
diabetic patients undergoing Emergency
Laparotomies.
• To compare the post operative mortality rate
in diabetic and non diabetic patients
undergoing Emergency Laparotomies.
2

INTRODUCTION
• Prediction of serious complications and
mortality are essential part of risk
management in surgery [1].
• Knowing which patient is at risk of developing
complications or dying contributes to the
quality of surgical care and cost reduction in
surgery [1].
3

• It is therefore essential to identify and make appropriate decision on those patients
who are at high-risk of developing serious complications or die [1, 2, 4, 5].
•Postoperative mortality of patients who underwent laparotomy in Dr. DY Patil
Hospital was studied using Physiological and Operative Severity Score for the
enumeration of Mortality and Morbidity (POSSUM).
•Criteria for the diagnosis of diabetes mellitus:
Symptoms of diabetes plus random blood glucose concentration > 200mg/dl or
Fasting plasma glucose (8 hours) > 126mg/dl or
HBA1C >6.5% or
Two- hour plasma glucose > 200mg/dl during an oral glucose tolerance test.
1. Neary WD. The Physiological and operative Severity score for the enumeration of mortality and morbidity (POSSSUM). Br J Surg. 2003; 90:157-165.
2. Chang R. Individual outcome prediction models for predictive care unit. Lancet, 1989; 11:143-146.
3. Knaus WA, Wagner DP, Draper EA et al. the POSSUM III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized patients. Chest1, 991; 100:1619-
1636.
4. Copeland GP, Jones D, and Walter M. POSSUM: A Scoring system for surgical Audit. Br J Surg. 1991:356-360.
5. Bann SD. comparative Audit: The trouble with POSSUM. JR Soc. Med, 2001; 94:632-634.
4

MATERIALS & METHODS
• Place of study: Dr. D. Y. Patil Medical College, Hospital and
Research Centre
• Period of study: July 2014 – June 2015
Data collection 1 year
• Type of study : Prospective study
• Sample size : 60 cases (Group A + Group B)
• Plan of study : The patients were divided in two groups
 Group A – 30 Patients undergoing emergency
Laparotomy who are known cases of Diabetes Mellitus as
well as those whose random BSL>200 mg/dl preoperatively
 Group B – 30 Patients undergoing emergency
Laparotomy who are non Diabetic
5

• Inclusion criteria: - All patients who
underwent emergency laparotomies 18 yrs
age & above.
• Exclusion criteria:
 Immuno-compromised patients
 Patients with Malignancies
 Patients with Chronic Obstructive Pulmonary Diseases.
 Gynecological and Urological Emergencies
 Pediatric Age group
• Institutional ethical committee approval was
taken prior to start of study.
6

On Admission
• Laboratory investigations:
 Haemogram,
 Liver Function Tests,
 Renal Function Tests,
 Serum Amylase,
 Serum Lipase,
 Serum Electrolytes,
 Blood Sugar Level (Random),
 Urine routine and microscopy.
• Cardiology Investigations were Electrocardiogram & 2 D Echo Cardiography
• Radiological Investigations:
 X-ray Erect Abdomen
 X-ray Chest
 Ultra sonography Abdomen and Pelvis
 Contrast Enhanced Computerised Tomography- Scan- Abdomen and pelvis if needed.
 Plain Computerised Tomography scan Abdomen & pelvis (if RFTs deranged)
7

Pre operative Preparation
• Consents obtained:
 Informed & Written consent
 SICU/Ventillator Consent
 High Risk Consent
• Patients grouped according to their Diabetic status.
• Ryle’s Tube insertion of appropriate size
• Foley’s catheterization of appropriate size
• IV Fluids 2 points of NS & RL 500 ml each
• Inj.ceftriaxone 1gm i.v 12 hrly empirically
• Inj. Metronidazole 500 mg i.v 8 hrly empirically
• All patients scrubbed with Povidone iodine scrub prior to surgery.
• Preparation of operative part was done with epilator in all patients.
• Patients shifted in OT dress on trolleys to the OT after preparation & pre anaesthetic
checkup...
• Adequate amount of blood or its components were reserved depending upon the
Haemogram values preoperatively, as well as by assessing the projected blood loss
intraoperative and the requirement of blood postoperatively in consultation with the
anaesthetists.
8

ON THE OT TABLE
• All patients undergoing emergency laparotomy were administered General Anaesthesia
• Epigastric midline extending inferiorly to median infra umbilical incision was taken.
• In diabetic patients undergoing emergency laparotomy Pre Op BSL was checked and
according to BSL value Inj. Human Actrapid was given according to sliding scale
Subcutaneously.
• Intra operatively BSL monitoring was done every 1 hourly and Inj. Human Actrapid was
given according to sliding scale subcutaneously.
• Intra operatively all the vitals such as pulse BP, RR, Temperature were monitored by the
anaesthetists and appropriate anaesthetic management was done where required.
9

BSL
VALUE
UNITS OF
INSULIN
0-150 0
151-200 4
201-250 8
251-300 12
301-350 16
351-400
>400
20
Urine Ketones
sent.
Inj. Human Actrapid Sliding Scale
10

• Closure of laparotomy wound was done in the following steps;
 Peritoneum was closed using Vicryl 2-0 round bodied absorbable sutures.
 Rectus sheath was closed using loop ethilon 1 suture.
 Intra abdominal drains were placed in Left and Right paracolic gutter where needed using
Kocher’s forceps on either side of the abdomen after closure of peritoneum separately
from the suture line.
 Skin was closed using ethilon 2-0 non absorbable sutures
 Dressing done after applying povidone iodine soaked sterile gauze pieces with sterile
pads over the suture line.
 Dynaplast applied over the pad and mesentery dressing applied over the drain.
11

Choice of wards post operatively
• Diabetic Patients undergoing Emergency laparotomy
 admitted in the Surgical Intensive Care Unit of the hospital if BSL level post operatively
deranged along with patient being haemodynamically unstable.
 If BSL levels within normal limits and patient is haemodynamically stable: admitted to
respective Surgery Wards.
• Non diabetic patients undergoing emergency laparotomy
 admitted in respective surgery wards.
 Hemodynamic Instability then admitted in Surgical Intensive Care Unit of the hospital
12

Shifting out of SICU
• Diabetic Patients undergoing Emergency laparotomy
 BSL under control .
 Haemodynamically stable irrespective of the post operative day.
• Non diabetic patients undergoing emergency laparotomy
 Haemodynamically stable irrespective of the post operative day
13

Post Operative Care for Diabetic Patients
• Inj. Human Actrapid according to sliding scale subcutaneously.
• BSL charting was done for diabetic patients as well as those patients who had random blood sugar
more than 200 mg/dl preoperatively.
• Fasting Lipid Profile and HBA1C were studied on Post operative day 1 for diabetic patients as well as
those patients who had random blood sugar more than 200 mg/dl preoperatively.
• BSL charting was done 8 hrly till patient was kept Nil by Mouth.
• As soon as Bowel Sounds on auscultation were established & flatus was passed Diabetic diet was
started.
• After Diabetic diet was started, BSL Fasting, Post Prandial 1 & Post Prandial 2 was studied in these
patients.
• Values of BSL charts, Fasting lipid profile and HBA1C studied & appropriate fixed dose Insulin along
with other appropriate hypoglycemic drugs were given after consultation with the physicians at the
hospital.
14

• All vitals of the patient such as pulse BP Temperature and Respiratory rate and spo2 monitored
adequately.
• Post operatively Ryle’s tube aspiration was done every 2 hourly and continuous connection was
done and chart was studied 12 hrly till it was in situ.
• Urine output charts were studied 12 hourly till discharge.
• Drain output charting was done every 12 hourly till it was in situ. In cases where drain output was
found to be less than 5 ml for consecutive 3 days, drains were removed irrespective of post
operative day.
• Inj.ceftriaxone 1 g IV 12 hrly, Inj. Metronidazole 500 mg IV tds, Inj. Amikacin 500 mg IV 12 hrly was
given to all patients empirically post operatively for 3 days.
• If the Renal function Tests were found to be deranged either preoperatively or post operatively then
then Inj. Amikacin and all other amino glycosides as well as nephrotoxic drugs were omitted.
• Later on Antibiotics were given as per culture and sensitivity report of post operative wound or
peritoneal fluid.
• Inj. Pantoprazole 40 mg IV 12 hrly was given to all patients post operatively.
• Inj Tramadol 1 amp in 100 ml NS IV 12 hrly was given to all patients postoperatively.
• Inj. Ondensetron 4 mg IV 12 hrly was given to all patients postoperatively.
• 5 points of IV fluids i.e NS/ RL alternately.
15

Dressing Protocol Diabetic Patients
• Check dressing was done under all aseptic precaution after 48 hours of surgery.
• Afterwards daily dressings were done till both drains & sutures were removed.
• If any discharge or collection was present, then according to site of collection or
discharge 1 or 2 sutures were removed and sent for pus culture and sensitivity.
According to the culture and sensitivity report appropriate antibiotics were started.
16

Post Operative Care for Non Diabetic Patients
• All vitals of the patient such as pulse BP Temperature and Respiratory rate and spo2 monitored
adequately.
• Post operatively Ryle’s tube aspiration was done every 2 hourly and continuous connection was done
and chart was studied 12 hrly till it was in situ.
• Urine output charts were studied 12 hourly till discharge.
• Drain output charting was done every 12 hourly till drain was in situ. In cases where drain output
was found to be less than 5 ml for consecutive 3 days, drains were removed irrespective of post
operative day.
• Inj.ceftriaxone 1 g IV 12 hrly, Inj. Metronidazole 500 mg IV 12 hrly, Inj. Amikacin 500 mg IV 12 hrly
was given to all patients empirically post operatively for 3 days.
• If the Renal function Tests were found to be deranged either preoperatively or post operatively in
then Inj. Amikacin and all other amino glycosides as well as nephrotoxic drugs were omitted.
• Later on Antibiotics were given as per culture and sensitivity report of post operative wound or
peritoneal fluid.
• Inj. Pantoprazole 40 mg IV 12 hrly was given to all patients post operatively.
• Inj Tramadol 1 amp in 100 ml NS IV 12 hrly was given to all patients postoperatively.
• Inj. Ondensetron 4 mg IV 12 hrly was given to all patients postoperatively.
• 5 points of IV fluids i.e NS/ RL alternately.
17

Dressing Protocol Non Diabetic Patients
• Check dressing was done under all aseptic precaution after 48 hours of surgery.
• If any discharge or collection was present, then according to site of collection or discharge 1
or 2 sutures were removed and sent for pus culture and sensitivity. According to the culture
and sensitivity report appropriate antibiotics were started.
• Afterwards daily dressings were done till both drains & sutures were removed.
18

Discharge Protocol for Diabetic Patients
• Wounds were healed completely.
• Haemodynamically stable.
• Patient mobilized.
• Patient taking adequate diabetic diet.
• BSL found within normal limits.
• Compliance with regular prescribed medications.
• Diabetic patients were asked to consult physicians on monthly basis for monitoring their BSL.
• Alteration/Tapering of dosage of medications was done accordingly.
19

Discharge Protocol of Non Diabetic Patients
• Wounds were healed completely.
• Haemodynamically stable.
• Patient mobilized.
• Patient taking adequate diet.
• Compliance with regular medications.
20

Mortality
• All non diabetic and diabetic patients who underwent emergency laparotomy and did not
survive post operatively were issued death certificates in line with the norms prescribed from
time to time by the appropriate authorities in the Government of Maharashtra.
• All non diabetic and diabetic patients who underwent emergency laparotomy and did not
survive post operatively were taken as subjects of mortality for our comparative study.
• In our study total 60 patients were studied out of which 6 did not survive post operatively.
Out of these 6 patients 4 patients were diabetic patients and 2 were non diabetic patients
21

23
Age Diabetic Non Diabetic
18-30 0 0
31-50 1 0
51-70 2 2
71-90 1 0
AGE DISTRIBUTION OF MORTALITY
Table 1: Age Distribution of mortality:
INFERENCE:
Maximum number of non diabetics’ patients undergoing emergency laparotomies
were in age group of 31-50 & maximum number of diabetic patients undergoing
emergency laparotomies were in age group 51-70.

24
Sex Diabetics Non Diabetics
Males 3 1
Females 1 1
SEX DISTRIBUTION OF MORTALITY
INFERENCE: Max. number of male diabetics suffered mortality in our study.

25
Emergency Laparotomy Diabetics Non Diabetics
Perforation Peritonitis 20 27
Haemoperitoneum 2 1
Intestinal Obstruction 8 2
INDICATIONS FOR EMERGENCY LAPAROTOMY IN DIABETICS & NON DIABETICS
.
Inference: In our study max. number of non diabetic patients underwent
emergency laparotomy for perforation peritonitis ans max. number of diabetic
patients underwent surgeries for intestinal obstruction.

26
Causes Diabetics Non Diabetics
Septicemia 2 2
Respiratory Failure 1 0
Multiorgan failure i.e Renal
failure, cardiac
failure(silent MI)
1 0
CAUSES FOR MORTALITY IN DIABETICS AND NON DIABETICS WHO UNDERWENT EMERGENCY LAPAROTOMY
Inference: In our study the number of patients dying due to septicemia was same
whereas diabetics were more prone to have mortality due to respiratory failure &
multiorgan failure.

27
Post Operative Day Diabetics Non Diabetics
1-5 1 0
6-10 1 1
11-15 1 0
16-20 0 1
>21 1 0
POST OPERATIVE DURATION OF MORTALITY
Inference: In our study, no significant difference was seen in the post operative day on
which deaths occurred.

28
Microorganisms Diabetics Non Diabetics
E.Coli 1 0
Klebsiella Pneumoniae 1 1
Methicillin Resistant
Staphylococcus Aureus
0 1
Microorganisms isolated from blood culture in septicemia patients who had mortality
Inference: In our study diabetic patients had E.Coli and Klebsiella Pneumonia in their
blood cultures whereas non diabetic patients had Klebsiella Pneumonia & MRSA in their
cultures.

DISCUSSION
1) In a study conducted by S Shetty et al. Comparison of early post operative
complications on laparotomies on diabetics and non diabetics- a study on south indian
population,[7] they concluded that mortality in diabetic patients is 8.5% v/s 3.3% in non
diabetic patients.
• In our study, the 30 day mortality rate for all 60 patients undergoing emergency laparotomies
was 10%.
• In our study, the 30 day mortality rate for diabetic patients was 13.3% and non diabetic
patients was 6.7% which is slightly higher than the study conducted by S.Shetty et al. as
quoted above.
• In our study, there was no mortality for patients both diabetic and non diabetic aged 18-30
years. In patients aged 31-50 the mortality rate was 6.67% each for diabetic and non
diabetic patients. For patients aged 71-90 the mortality rate for diabetic patients was 3.33%
and there was no mortality for non diabetic patients.
• In our study we found that the mortality rate due to septic shock was 6.67% each in diabetic
and non diabetic patients. These patients went into septic shock due to anastomotic leak.
This is slightly higher than study conducted by S. Shetty et al. In their study percentage of
patients i.e diabetic and non diabetic having anastomotic leak was 3.4% and 1.9%
respectively.
29

• In a study conducted by Kimberly Steidy et al. [8] Patients with AKI had fewer ventilator-free and
intensive care unit free days and a decreased likelihood of discharge to home. Morbidity and
mortality increased with severity of AKI, and AKI of any severity was found to be a strong predictor
of hospital mortality (odds ratio, 10.59; 95% confidence interval, 1.28Y87.35; p = 0.03) in surgical
sepsis.
• In our study one patient was in diabetic Ketoacidosis pre operatively; after undergoing
emergency laparotomy he had hypokalemia post operatively and hyper natremia which led
to Acute kidney injury progressing to End stage kidney disease and subsequently renal
failure hence the patient did not survive post operatively.
• In our study the mortality rate due to Diabetic kidney disease was 3.33%.
30
6) A R, S Shetty, S Rai, R Bhat, S Rao, P Thejeswi, P , S R HS Comparison of early post operative complications of laparotomies in diabetics andd non diabetics- A
study on south Indain population Internet scientific publications Volume 13 Issue 3
7) Kimberly Reidy,1,2 Hyun Mi Kang,1 Thomas Hostetter,3 and Katalin Susztak1 Molecular mechanisms of diabetic kidney disease The Journal of Clinical
Investigation Volume 124 Number 6 June 2014 Pg. 2333-2340

Conclusion
• Diabetic patients are more prone to mortality than non diabetic patients.
• Mortality rate in diabetic patients in our study has been found to be 13.3% and in non
diabetic patients 6.7%.
• Good BSL control post operatively helps in reduction of mortality significantly.
• Decision of Emergency Laparotomy should be taken & proceeded with irrespective of
diabetic or non diabetic patients if it is life saving.
• Diabetic Ketoacidosis post operatively leads to multi organ failure & causes mortality.
• Septicemia post operatively leads to septic shock thereby leading to decreased perfusion
leading to hypoxia & ultimately death in both diabetic & non diabetic patients.
• Renal failure pre operatively & post operatively increases the mortality rate significantly in
diabetic patients.
31

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