SlideShare a Scribd company logo

Paper tsc june 2021

Download as DOCX, PDF
••
A
aissmsblogs

The document is a review by Dr. Trupti Chitre that explores pyrimidine pharmacophores as thymidine monophosphate kinase inhibitors for antitubercular activity. It highlights the urgent need for new antitubercular agents due to the rise of drug-resistant tuberculosis strains. The review emphasizes structure-activity relationship studies and computational analyses of nucleotide and nucleoside derivatives of pyrimidine analogs as potential TMPKMT inhibitors.

Education
1 of 1
Download to read offline
1
Researchpaper of Dr. Trupti Chitre Title: ExploringPyrimidinePharmacophoreasThymidineMonophosphate Kinase Inhibitorsfor AntitubercularActivity:A Review Authors: Trupti SameerChitre*,Kalyani DhirendraAsgaonkar,Shital Manoj Patil , Muthu KumaradossKathiravanandSubhashBalkrishnaPadhye Journal Details: CurrentTopicsin Medicinal Chemistry,2016, 16, 3211-3223 Publisher: BenthamScience Publishers Description: Tuberculosis(TB) hasbeen declaredasahealthemergencydue to emergence of resistant strains of M. tuberculosis, multidrug resistant (MDR), extensively drug resistant (XDR) TB strains and totally drug resistant tuberculosis (TDR-TB) reported recently in some parts of the world. Therefore, the current situation necessitates developing new antitubercular agents acting on novel targets for effectivelycontrollingTB.Thymidine Monophosphate Kinase (TMPKmt) enzyme is one such target, which is being explored. This review focuses on Structure Activity Relationship studies (SARs) and computational studies of various nucleotide and nucleoside derivatives of pyrimidine analogs reported as TMPKmt inhibitors. Photographs :

More Related Content

PPTX
Exp 1 5th sem
Nathani Zeeshan
 
DOCX
ABSTRACT
Sadaf Mukadam
 
PDF
Drug resistance and multiple drug therapy-by Dr.Jibachha Sah
Dr. Jibachha Sah
 
PPT
Introduction new ppt!
vishwajeeta
 
PDF
Paper publications details of all Staff-2019-20(Other).xlsx - M R Talware.pdf
aissmsblogs
 
PPTX
PPT- RVN (1).pptx
aissmsblogs
 
PDF
Newsletter _Brother’s kitchen. updated.pdf
aissmsblogs
 
PDF
45 (1)
aissmsblogs
 
Exp 1 5th sem
Nathani Zeeshan
 
ABSTRACT
Sadaf Mukadam
 
Drug resistance and multiple drug therapy-by Dr.Jibachha Sah
Dr. Jibachha Sah
 
Introduction new ppt!
vishwajeeta
 
Paper publications details of all Staff-2019-20(Other).xlsx - M R Talware.pdf
aissmsblogs
 
PPT- RVN (1).pptx
aissmsblogs
 
Newsletter _Brother’s kitchen. updated.pdf
aissmsblogs
 
45 (1)
aissmsblogs
 

More from aissmsblogs (20)

DOCX
Research paper description suk
aissmsblogs
 
DOCX
Research paper mrpr
aissmsblogs
 
PDF
Ijsartv6 i336124
aissmsblogs
 
PDF
356 358,tesma411,ijeast
aissmsblogs
 
PDF
422 3 smart_e-health_care_using_iot_and_machine_learning
aissmsblogs
 
PDF
Ijsartv6 i336122
aissmsblogs
 
PDF
Ijsrdv6 i120151
aissmsblogs
 
PDF
Ijsrdv8 i10424
aissmsblogs
 
PDF
Ijsrdv8 i10550
aissmsblogs
 
PDF
Ijsrdv8 i10355
aissmsblogs
 
PDF
Ijsrdv8 i10398
aissmsblogs
 
PDF
Ijsrdv7 i10842
aissmsblogs
 
PDF
Ijsrdv8 i10772
aissmsblogs
 
PDF
Irjet v7 i3570
aissmsblogs
 
PDF
Irjet v7 i3811
aissmsblogs
 
PDF
Irjet v7 i3290
aissmsblogs
 
PDF
Ijsrdv7 i10318
aissmsblogs
 
PDF
Irjet v7 i31040
aissmsblogs
 
PDF
Irjet v7 i3475
aissmsblogs
 
PDF
43 automatic
aissmsblogs
 
Research paper description suk
aissmsblogs
 
Research paper mrpr
aissmsblogs
 
Ijsartv6 i336124
aissmsblogs
 
356 358,tesma411,ijeast
aissmsblogs
 
422 3 smart_e-health_care_using_iot_and_machine_learning
aissmsblogs
 
Ijsartv6 i336122
aissmsblogs
 
Ijsrdv6 i120151
aissmsblogs
 
Ijsrdv8 i10424
aissmsblogs
 
Ijsrdv8 i10550
aissmsblogs
 
Ijsrdv8 i10355
aissmsblogs
 
Ijsrdv8 i10398
aissmsblogs
 
Ijsrdv7 i10842
aissmsblogs
 
Ijsrdv8 i10772
aissmsblogs
 
Irjet v7 i3570
aissmsblogs
 
Irjet v7 i3811
aissmsblogs
 
Irjet v7 i3290
aissmsblogs
 
Ijsrdv7 i10318
aissmsblogs
 
Irjet v7 i31040
aissmsblogs
 
Irjet v7 i3475
aissmsblogs
 
43 automatic
aissmsblogs
 
Ad

Recently uploaded (20)

PPTX
A Smarter Way to Think About Choosing a College
Cyndy McDonald
 
DOCX
Unit 5: Speech-language and swallowing disorders
JELLA VISHNU DURGA PRASAD
 
PPTX
Tips Management in Odoo 18 POS - Odoo Slides
Celine George
 
PPTX
20250924 Navigating the Future: How to tell the difference between an emergen...
McGuinness Institute
 
PPTX
HEALTH CARE DELIVERY SYSTEM - UNIT 2 - GNM 3RD YEAR.pptx
Priyanshu Anand
 
PDF
Health-The-Ultimate-Treasure (1).pdf/8th class science curiosity /samyans edu...
Sandeep Swamy
 
PPTX
Python-Application-in-Drug-Design by R D Jawarkar.pptx
Rahul Jawarkar
 
PPTX
PROTIEN ENERGY MALNUTRITION: NURSING MANAGEMENT.pptx
PRADEEP ABOTHU
 
PPTX
How to Track Skills & Contracts Using Odoo 18 Employee
Celine George
 
PPTX
Continental Accounting in Odoo 18 - Odoo Slides
Celine George
 
PDF
The Minister of Tourism, Culture and Creative Arts, Abla Dzifa Gomashie has e...
nservice241
 
PPTX
Kanban Cards _ Mass Action in Odoo 18.2 - Odoo Slides
Celine George
 
PDF
Review of Related Literature & Studies.pdf
Thelma Villaflores
 
PPTX
CDH. pptx
AneetaSharma15
 
PPTX
INTESTINALPARASITES OR WORM INFESTATIONS.pptx
PRADEEP ABOTHU
 
PPTX
BASICS IN COMPUTER APPLICATIONS - UNIT I
suganthim28
 
PPTX
Virus sequence retrieval from NCBI database
yamunaK13
 
PPTX
family health care settings home visit - unit 6 - chn 1 - gnm 1st year.pptx
Priyanshu Anand
 
PPTX
Command Palatte in Odoo 18.1 Spreadsheet - Odoo Slides
Celine George
 
DOCX
Modul Ajar Deep Learning Bahasa Inggris Kelas 11 Terbaru 2025
wahyurestu63
 
A Smarter Way to Think About Choosing a College
Cyndy McDonald
 
Unit 5: Speech-language and swallowing disorders
JELLA VISHNU DURGA PRASAD
 
Tips Management in Odoo 18 POS - Odoo Slides
Celine George
 
20250924 Navigating the Future: How to tell the difference between an emergen...
McGuinness Institute
 
HEALTH CARE DELIVERY SYSTEM - UNIT 2 - GNM 3RD YEAR.pptx
Priyanshu Anand
 
Health-The-Ultimate-Treasure (1).pdf/8th class science curiosity /samyans edu...
Sandeep Swamy
 
Python-Application-in-Drug-Design by R D Jawarkar.pptx
Rahul Jawarkar
 
PROTIEN ENERGY MALNUTRITION: NURSING MANAGEMENT.pptx
PRADEEP ABOTHU
 
How to Track Skills & Contracts Using Odoo 18 Employee
Celine George
 
Continental Accounting in Odoo 18 - Odoo Slides
Celine George
 
The Minister of Tourism, Culture and Creative Arts, Abla Dzifa Gomashie has e...
nservice241
 
Kanban Cards _ Mass Action in Odoo 18.2 - Odoo Slides
Celine George
 
Review of Related Literature & Studies.pdf
Thelma Villaflores
 
CDH. pptx
AneetaSharma15
 
INTESTINALPARASITES OR WORM INFESTATIONS.pptx
PRADEEP ABOTHU
 
BASICS IN COMPUTER APPLICATIONS - UNIT I
suganthim28
 
Virus sequence retrieval from NCBI database
yamunaK13
 
family health care settings home visit - unit 6 - chn 1 - gnm 1st year.pptx
Priyanshu Anand
 
Command Palatte in Odoo 18.1 Spreadsheet - Odoo Slides
Celine George
 
Modul Ajar Deep Learning Bahasa Inggris Kelas 11 Terbaru 2025
wahyurestu63
 
Ad

Paper tsc june 2021

  • 1. Researchpaper of Dr. Trupti Chitre Title: ExploringPyrimidinePharmacophoreasThymidineMonophosphate Kinase Inhibitorsfor AntitubercularActivity:A Review Authors: Trupti SameerChitre*,Kalyani DhirendraAsgaonkar,Shital Manoj Patil , Muthu KumaradossKathiravanandSubhashBalkrishnaPadhye Journal Details: CurrentTopicsin Medicinal Chemistry,2016, 16, 3211-3223 Publisher: BenthamScience Publishers Description: Tuberculosis(TB) hasbeen declaredasahealthemergencydue to emergence of resistant strains of M. tuberculosis, multidrug resistant (MDR), extensively drug resistant (XDR) TB strains and totally drug resistant tuberculosis (TDR-TB) reported recently in some parts of the world. Therefore, the current situation necessitates developing new antitubercular agents acting on novel targets for effectivelycontrollingTB.Thymidine Monophosphate Kinase (TMPKmt) enzyme is one such target, which is being explored. This review focuses on Structure Activity Relationship studies (SARs) and computational studies of various nucleotide and nucleoside derivatives of pyrimidine analogs reported as TMPKmt inhibitors. Photographs :