PEPTIC ULCER
PRESENTED BY:
MR. ABHAY RAJPOOT
INTROCDUCTION
 It is defined as a breakdown in continuity of mucus membrane of duodenum,
esophagus and stomach by pepsin and acid are present in abnormally high
concentrations.
 Peptic ulcers are sores that develop in the lining of the stomach, lower
esophagus, or small intestine. They're usually formed as a result of inflammation
caused by the bacteria H. pylori, as well as from erosion from stomach acids.
DEFINITION
 Peptic ulcers are open sores that develop on the inside lining of stomach and the
upper portion of small intestine
TYPES
There are three types of peptic ulcers:
 Gastric ulcers: ulcers that develop inside the stomach
 Esophageal ulcers: ulcers that develop inside the esophagus
 Duodenal ulcers: ulcers that develop in the upper section of the
small intestines, called the duodenum
ETIOLOGY
 Helicobacter pylori (H. pylori), a type of bacteria that can cause a stomach
infection and inflammation
 Frequent use of aspirin or other anti-inflammatory drugs (risk associated
with this behaviour increases in women and people over the age of 60)
 Smoking
 Drinking too much alcohol
 Radiation therapy
 Stomach cancer
PATHOPHYSIOLOGY
CLINICAL MANIFESTATIONS
 The most common symptom of a peptic ulcer is burning abdominal pain that extends
from the navel to the chest, which can range from mild to severe. In some cases, the
pain may wake you up at night. Small peptic ulcers may not produce any symptoms in
the early phases.
 Other common signs of a peptic ulcer include:
 Changes in appetite
 Nausea
 Bloody or dark stools
 Unexplained weight loss
 Indigestion
 Vomiting
 Chest pain
Diagnostic tests
 Medical history
 Physical Exam
 Lab tests
 Upper gastrointestinal (GI) endoscopy and biopsy
 Upper GI series
 Computerized tomography (CT) scan
COMPLICATIONS
MANAGEMENT
 Antibiotic medications to kill H. pylori. If H. pylori is found in your digestive
tract, your doctor may recommend a combination of antibiotics to kill the
bacterium. These may include amoxicillin (Amoxil), clarithromycin (Biaxin),
metronidazole.
 Proton pump inhibitors — also called PPIs — reduce stomach acid by
blocking the action of the parts of cells that produce acid. These drugs include
the prescription and over-the-counter medications omeprazole (Prilosec),
lansoprazole (Prevacid).
 Acid blockers — also called histamine (H-2) blockers — reduce the amount of
stomach acid released into your digestive tract, which relieves ulcer pain and
encourages healing….ex. ranitidine
 Antacids neutralize existing stomach acid and can provide rapid pain relief.
Side effects can include constipation or diarrhea, depending on the main
ingredients.
THANK YOU

Peptic ulcer

  • 1.
  • 2.
    INTROCDUCTION  It isdefined as a breakdown in continuity of mucus membrane of duodenum, esophagus and stomach by pepsin and acid are present in abnormally high concentrations.  Peptic ulcers are sores that develop in the lining of the stomach, lower esophagus, or small intestine. They're usually formed as a result of inflammation caused by the bacteria H. pylori, as well as from erosion from stomach acids.
  • 4.
    DEFINITION  Peptic ulcersare open sores that develop on the inside lining of stomach and the upper portion of small intestine
  • 5.
    TYPES There are threetypes of peptic ulcers:  Gastric ulcers: ulcers that develop inside the stomach  Esophageal ulcers: ulcers that develop inside the esophagus  Duodenal ulcers: ulcers that develop in the upper section of the small intestines, called the duodenum
  • 7.
    ETIOLOGY  Helicobacter pylori(H. pylori), a type of bacteria that can cause a stomach infection and inflammation  Frequent use of aspirin or other anti-inflammatory drugs (risk associated with this behaviour increases in women and people over the age of 60)  Smoking  Drinking too much alcohol  Radiation therapy  Stomach cancer
  • 8.
  • 10.
    CLINICAL MANIFESTATIONS  Themost common symptom of a peptic ulcer is burning abdominal pain that extends from the navel to the chest, which can range from mild to severe. In some cases, the pain may wake you up at night. Small peptic ulcers may not produce any symptoms in the early phases.  Other common signs of a peptic ulcer include:  Changes in appetite  Nausea  Bloody or dark stools  Unexplained weight loss  Indigestion  Vomiting  Chest pain
  • 11.
    Diagnostic tests  Medicalhistory  Physical Exam  Lab tests  Upper gastrointestinal (GI) endoscopy and biopsy  Upper GI series  Computerized tomography (CT) scan
  • 13.
  • 14.
    MANAGEMENT  Antibiotic medicationsto kill H. pylori. If H. pylori is found in your digestive tract, your doctor may recommend a combination of antibiotics to kill the bacterium. These may include amoxicillin (Amoxil), clarithromycin (Biaxin), metronidazole.  Proton pump inhibitors — also called PPIs — reduce stomach acid by blocking the action of the parts of cells that produce acid. These drugs include the prescription and over-the-counter medications omeprazole (Prilosec), lansoprazole (Prevacid).  Acid blockers — also called histamine (H-2) blockers — reduce the amount of stomach acid released into your digestive tract, which relieves ulcer pain and encourages healing….ex. ranitidine
  • 15.
     Antacids neutralizeexisting stomach acid and can provide rapid pain relief. Side effects can include constipation or diarrhea, depending on the main ingredients.
  • 16.