This document outlines a proposed study on the health impacts of climate change on indigenous communities in the Peruvian Amazon. It will implement a 3-year cohort study with approximately 1,000 participants from the Shawi and Shipibo-Konibo ethnic groups. The study aims to estimate the incidence of waterborne, respiratory, vector-borne, and skin diseases, as well as STIs. It will identify individual and environmental risk factors. Data will be collected through standardized questionnaires, clinical evaluations, anthropometrics, and laboratory tests. Results will be disseminated annually through meetings with community members, indigenous leaders, and national authorities.