Pleural effusion is an abnormal collection of fluid in the pleural space between the lungs and chest wall. It can occur when fluid builds up faster than it drains away and common causes include congestive heart failure, pneumonia, and cancer. Diagnosis involves chest x-rays, CT scans, or analyzing fluid drawn from the pleural space during a thoracentesis procedure. Treatment depends on the underlying cause but may include diuretics, antibiotics, drainage of fluid, or surgery in severe cases.