This document discusses the issue of polypharmacy in older adults. Polypharmacy is defined as the concurrent use of multiple medications, which increases the risks of morbidity and mortality in older adults. Specifically, 30% of older adults see two or more physicians, 50% are prescribed five or more medications, and 41% of those aged 65+ are admitted to the hospital due to polypharmacy. Physiological effects in older adults include nonspecific complaints caused by drug interactions and toxicity that lead to increased morbidity and mortality. The Beers Criteria is presented as a clinical tool for nurses to evaluate inappropriate medications, excess dosages, and drug-disease interactions to avoid in older adults in order to reduce the risks of polypharmacy