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PPT on Tetracycline antibiotic (2).pdf
- 1. Tetracycline Presented by :-Khushbu Kumari Roll no. :- 201631 Department of Biotechnology Central University of Haryana
- 2. General introduction What isTetracycline ? Tetracycline is an antibiotic that fights against infection caused by bacteria. Belongs to a family of broad spectrum antibiotics effective against remarkably wide variety of organisms. Tetracycline is used to treat many different bacterial infections of the skin, intestines, respiratory tract, urinary tract, genitals, lymph nodes, and other body systems. It is often used in treating severe acne, or sexually transmitted diseases such as syphilis, gonorrhea. Isolated directly from several species of Streptomyces bacteria or produced semi-synthetically from those isolated compounds.
- 3. History Chlortetracycline (trade nameAureomycin, Lederle Laboratories) is a tetracycline antibiotic, the first tetracycline to be identified. It was discovered in 1945 at Lederle Laboratories under the supervision of scientist Yellapragada Subbarow and Benjamin Minge Duggar. Duggar identified the antibiotic as the product of an actinomycete he cultured from a soil sample collected from Sanborn Field at the University of Missouri.The organism was named Streptomyces aureofaciens and the isolated drug, Aureomycin, because of their golden color. Chlortetracycline
- 4. Classification of tetracycline ●On the basis of sources: ● On the basis of duration of action: (i) Short acting tetracyclines(half life 6-8 hrs): Chlortetracycline, oxytetracycline and tetracycline. (ii) Intermediate acting tetracyclines (half life 12 hrs): Demeclocycline and methacycline. (iii) Long acting tetracyclines(half life 16 hrs): Doxycycline and minocycline. Naturally occuring ● Tetracycline ● Chlortetracycline ● Oxytetracycline ● Demeclocycline Semi synthetic ● Doxycycline ● Meclocycline ● Methacycline ● Minocycline
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- 7. Mechanism of action ●They are short-acting and passively diffuse through porin channels in the bacterial membrane. ● They inhibit protein synthesis by binding reversibly to the bacterial 30S ribosomal subunit and preventing the aminoacyl tRNA from binding to the A site of the ribosome. ● They also bind to some extent the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular components to leak from bacterial cells.
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- 9. Pharmacokinetics Tetracyclines can bedivided into three main groups based on Pharmacokinetics
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- 12. Adverse effects ● Teethand bones damage ● Cause skin reaction ● Nail fluorescence
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