Presentation (4)

Presentation (4)

• 1.
  PROGESTIN
• 2.
  DEFENITION • PROGESTINS aresynthetic forms of bodily naturely occurring Hormone PROGESTERONE • Progestins are interact with Progesterone receptors of the body and cause progesterone like effects
• 3.
  GENERIC NAMES • HYDROXYPROGESTERONE • MEDROXYPROGESTERONE • DYDROGESTERONE • NORETHINDRONE • LYNESTRENOL • ALLYLESTERENOL • LEVONOGESTRAL
• 4.
  TRADE NAMES • 1.HYDROXY PROGESTERONE • a) proloton • b) Depot • c) procarpin • 2. MEDROXYPROGESTERONE • a) provera • b) farlutal • c) modus •
• 5.
  TRADE NAMES • 3.DYDROGESTERONE •a)Duphaston • 4. NORETHINDRONE • a) Norgest • b) Stypin • c) Regesterone
• 6.
  TRADE NAMES • 5.LYNESTRENOL •a) Orgametril • 6. ALLYLESTERENOL • a) Gestanin • b) Fetugard • c) Maintain • 7. LEVONORGESTRAL • a) Duoloton • b) Ovrel
• 7.
  DOSE ROUTE HYDROXY PROGESTERONE . PROLOTON .DEPOT . PROCARPIN 250-500ml Intramuscular MEDROXY PROGESTERONE . PROVERA . FARLUTAL . MODUS 5-20mg oral DYDRO GEATERONE . DUPHASTON 5-10mg oral
• 8.
  NORETHINDRONE . STYPIN . NORGEST .REGESTERONE LYNESTRENOL . ORGAMETRIL 5-10mg 5-10mg Oral oral ALLYLESTERENOL . GESTANIN . FETUGARD . MAINTANE 10-40mg oral LEVONORGESTRAL . DULOTON . OVRAL 0.1-0.5mg oral
• 10.
  INDICATIONS • . Asa contraceptive • . Dysfunctional uterine bleeding • . Endometriosis • . Endometrial carcinoma • . Progesterone inssuficiency • . Habitual abortion • . Premenstrual syndrome • . Hormone replacement therapy • . Breast malignancy • . Liver disease • . Theombo embolism • Depression • . Fluid retention • . Glucose intolerence • . Retinal thrombosis • . Hyper lipidemia • . Weight gain CONTRA INDICATIONS INDICATIONS&CONTRAINDICATIONS
• 11.
  ADVERSE EFFECTS • .Long term use of HRT leads to breast malignancy • . The blood sugar level elevation cause diabetes • . Intramuscular injection of progestins is painful • . Irregular bleeding may occur • . Rise of body temperature may occur • . If it given early pregnancy can cause masculinization of foetus • Congenital abnormalities
• 12.
  PHARMACOKINETICS • . Progesteroneis orally inactive because of high first pass metabolism in liver • . Most synthetic progestins are orally active and metabolized slowly at 8-24h • . The IM injection of it rapidly act plasma with 5-7minutes • .the oral administration of progestins is microfine particles of progesterone suspended in oil and dispensed in gelatin capsules it s absorption occur through lymphatics
• 13.
  NURSES RESPONSIBILITIES • .Asses the patient condition • . Collect the complete family history of patient have any • - Breast, endometrial, or renal cancer • - liver or kidney disease, endometrial hyperplasia • Obtain the history of patient is allergic to any drug • Asses the CV status of patient • Monitor lab test – LFT, Glucose level, Sodium, Chloride • . Monitor fluid and electrolyte balance • . Check vital signs of patient • . Check integumentry effects • . Check any emboli or weight gain