This document discusses strategies for preventing complications from modified radical mastectomy (MRM) procedures. It emphasizes the importance of thorough planning, execution with contingency adjustments, and strict adherence to aseptic technique. Key steps include carefully planning the incision to ensure adequate margins and avoid dog ears, creating a flap of appropriate thickness, performing a total mastectomy while controlling hemorrhage, and completing a thorough axillary dissection with hemostasis before closure. Drains should be placed laterally and medially as needed to reduce seroma formation post-operatively. With meticulous attention to each stage of the procedure, surgical complications and unwanted outcomes from MRM can be minimized.