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• Propranolol hydrochloride is a synthetic beta-adrenergic receptor-blocking
agent chemically described as 2-Propanol, and synthesized by 1-[(1-
methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride,(±)-.](https://image.slidesharecdn.com/propranolol-151019140401-lva1-app6891/75/Propranolol-2-2048.jpg)
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Propranolol
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- 2. Source • Propranolol hydrochlorideis a synthetic beta-adrenergic receptor-blocking agent chemically described as 2-Propanol, and synthesized by 1-[(1- methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride,(±)-.
- 3. Propranolol Pronunciation • GenericName: propranolol (pro PRAN oh lol) • Brand Names: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal • Dosage Form: capsule, extended release, Tablet.
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- 6. Mechanism Propranolol Selectively blocks theβ1-receptor in heart. Decreases force of contraction and heart rate and cardiac output. Decreases blood pressure.
- 7. Mechanism Propranolol Inhibits vasomotor conduction. Decreasessympathetic discharge. Vasodilation. Decreases blood pressure.
- 8. Mechanism propranolol Selectively blocks theβ1-receptor in kidney. Decreases renin secretion. Decreases the effects of renin angiotensin system. Decreases blood pressure.
- 9. Pharmacological effect • Thelevorotatory isomer of propranolol binds reversibly with ß1- and ß2- adrenoreceptors; both receptors have membrane stabilizing activity. • Propranolol leads to a reduction of the heart rate and of the cardiac output; initially the hypotensive effect is delayed because of peripheral vasoconstriction. • Propranolol also increases plasma renin activity and suppresses lipolysis. In the plasma the triglycerides increase, whereas the HDL cholesterol decreases slightly. • The bond between propranolol and ß2-receptors causes an increase of the airway resistance and the inhibition of glycogenolysis and gluconeogenesis.
- 10. Therapeutic Uses Propranolol isindicated for the management of various conditions, including: Hypertension. Angina pectoris (with the exception of variant angina). Tachyarrhythmias. Myocardial infarction. Control of tachycardia/tremor associated with anxiety, hyperthyroidism. Essential tremor. Migraine prevention. Cluster headache prevention. Hyperhidrosis. Proliferating infantile hemangioma.
- 11. Side effect Common sideeffects of propranolol: Chronic Trouble SleepingLess Severe Feeling WeakLess Severe Low Energy Infrequent side effects of propranolol: Bronchospasm Severe Chronic Heart Failure Severe DepressionSevere Diarrhea Rare side effects of propranolol: Abnormal Heart RhythmSevere Abnormally Low Blood PressureSevere Confused