ProxySQL is a MySQL protocol proxy that provides high availability, scalability, and security for MySQL database systems. It allows clients to connect to ProxySQL, which then evaluates requests and performs actions like routing queries to backend databases, caching reads, connection pooling, and load balancing across servers. ProxySQL's main features include query routing, firewalling, real-time statistics, monitoring, and management of large numbers of backend servers. The presentation discusses using ProxySQL's query routing and rewriting capabilities to mask sensitive data when replicating databases for development environments. It also covers using the REST API and Prometheus integration to configure ProxySQL and monitor metrics without direct SQL access.