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Rearrangement Reactions vikram choudhary
The presentation discusses rearrangement reactions, which involve the migration of an atom or group within a molecule to form a structural isomer. It defines rearrangement and provides examples of types including those to electron deficient carbons, nitrogens, and oxygens, as well as electron-rich carbons and aromatic systems. Mechanisms are presented for rearrangements involving migration to various electron-withdrawing or -releasing centers.
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Rearrangement Reactions vikram choudhary
- 1. Presented by: VikramChoudhary M. Pharm First Semester, School of Pharmacy, DAVV, Indore
- 2. Content of Presentation- What is Rearrangement ? Types of Rearrangement 1. Rearrangement to Electron Deficient Carbon 2. Rearrangement to Electron Deficient Nitrogen 3. Rearrangement to Electron Deficient Oxygen 4. Rearrangement to Electron-Rich Carbon 5. Aromatic Rearrangements
- 3. REARRANGEMENT REACTIONS • Arearrangement reaction is a broad class of organic reactions where the carbon skeleton of a molecule is rearranged to give a structural isomer of the original molecule. Often a substituent moves from one atom to another atom in the same molecule . • Rearrangement reactions involve the migration of a group or an atom from one center (migration origin) to another (migration terminus) within the same molecule. What is Rearrangement ?
- 4. Y Z XY W ZX W In the above-mentioned generalized representation, atom-X is migration origin from where the migrating group “W” moves to atom-Y (migration terminus ) REARRANGEMENT REACTIONS What is Rearrangement ? Cont’d
- 5. Types of Rearrangements 1.Rearrangement to Electron Deficient Carbon 2. Rearrangement to Electron Deficient Nitrogen 3. Rearrangement to Electron Deficient Oxygen 4. Rearrangement to Electron-Rich Carbon 5. Aromatic Rearrangements 5 Types of Rearrangements- REARRANGEMENT REACTIONS
- 6. Mechanism 1. Rearrangement toElectron Deficient Carbon REARRANGEMENT REACTIONS R'' R''' R' R OH R'' R''' R R' O H + H H
- 7. Mechanism REARRANGEMENT REACTIONS 1. Rearrangementto Electron Deficient Carbon Cont’d R'' R''' R' R OH R'' R''' R OH2 H R' -H2O R'' R''' R' R R'' R''' R OH2 R'' R''' R R' H
- 8. Mechanism REARRANGEMENT REACTIONS 1. Rearrangementto Electron Deficient Carbon Cont’d
- 9. Mechanism REARRANGEMENT REACTIONS 1. Rearrangementto Electron Deficient Carbon Cont’d
- 10. Mechanism REARRANGEMENT REACTIONS 1. Rearrangementto Electron Deficient Carbon Cont’d
- 11. REARRANGEMENT REACTIONS 2. Rearrangementto Electron Deficient Nitrogen Mechanism
- 12. Mechanism REARRANGEMENT REACTIONS 2. Rearrangementto Electron Deficient Nitrogen Cont’d
- 13. Mechanism REARRANGEMENT REACTIONS 3. Rearrangementto Electron Deficient Oxygen
- 14. Mechanism REARRANGEMENT REACTIONS 3. Rearrangementto Electron Deficient Oxygen Cont’d
- 15. Mechanism REARRANGEMENT REACTIONS 4. Rearrangementto Electron - Reach Carbon
- 16. Mechanism REARRANGEMENT REACTIONS 4. Rearrangementto Electron - Reach Carbon Cont’d
- 17. Mechanism REARRANGEMENT REACTIONS 5. AromaticRearrangements
- 18. Mechanism REARRANGEMENT REACTIONS 5. AromaticRearrangements Cont’d
- 19. Mechanism REARRANGEMENT REACTIONS 5. AromaticRearrangements Cont’d
- 20. Mechanism REARRANGEMENT REACTIONS 5. AromaticRearrangements Cont’d