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ABOUT THIS JOURNAL The Annual Review of Biophysics, in publication since 1972, covers significant developments in the field of Biophysics, including Macromolecular Structure, Function and Dynamics, Theoretical and Computational Biophysics, Molecular Biophysics of the Cell, Physical Systems Biology, Membrane Biophysics, Biotechnology, Nanotechnology, and Emerging Techniques. Add to Favorites EVOLUTIONARY RELATIONSHIPS AND STRUCTURAL MECHANISMS OF AAA+ PROTEINS Complex cellular events commonly depend on the activity of molecular “machines” that efficiently couple enzymatic and regulatory functions within a multiprotein assembly. Read more Jennifer A. Doudna, of the University of California, Berkeley, was interviewed in the radio program Radiolab about CRISPR-Cas, a protein that can be used as a genome-editing tool. She discusses how she came upon this insight as well as its implications. Read her articles in the Annual Review of Biochemistry and the Annual Review of Biophysics.