RHEUMATOID ARTHRITIS.pptx

RHEUMATOID ARTHRITIS.pptx

• 1.
  RHEUMATOID ARTHRITIS .
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  INTRODUCTION Rheumatoid Arthritis (RA)is a chronic autoimmune inflammatory disorder affecting many joints in hands nd feet leading to:- • Decline in functional status. • Work disability. • Systemic Complications. • Co-morbidity (is the presence of one or more additional disorders). • Increased mortality.
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  PATHOGENESIS The exact causeof RA is still unknown ,but research suggests that it is a multifactorial disease, meaning that it is caused by a combination of genetic , environmental , and immunological factors. GENETICS FACTORS: there is a genetic component to RA as individual with a family history of disease are more likely to develop it themselves. Certain genetic markers , such as the human leukocyte antigen (HLA) genes, have been associated with n increased risk of RA. Autoimmunity : RA is an autoimmune disease, meaning the immune system mistakenly attacks the body’s own tissues. In RA ,the immune system trgets the synovium membrane that lines the joints leading to chronic inflammation.
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  CONT.. Synovial inflammation: inRA the immune response triggers n inflammatory cascade within the synovium. This leads to infiltration of immune cells such as T-cells, B-cells