This article discusses the role of facial muscles in complete denture prosthesis construction. It describes the muscles of mastication (temporalis, masseter, medial and lateral pterygoid) and facial expression (orbicularis oris, buccinator). These muscles influence the peripheral extensions, shape, thickness of denture bases and position of teeth. Specifically, the orbicularis oris muscle affects the labial flange thickness, while the buccinator muscle influences the buccal flange and vestibule width. Understanding the actions of these muscles is important for successful denture fabrication and patient comfort.