The Ruby on Rails security guide outlines critical safety practices for managing sessions, preventing session hijacking, and countering cross-site request forgery (CSRF) attacks. It emphasizes the importance of secure session management, including secret keys and SSL configurations, while also addressing various injection attacks such as SQL injection and cross-site scripting (XSS). The document provides practical countermeasures to enhance web application security, including input validation, output escaping, and using safe coding practices.