Six Sigma is a structured process for defining, measuring, and controlling opportunities for improvement in repetitive processes. It can significantly reduce defects in healthcare by focusing on operational efficiency and translating patient needs into defined tasks. While Six Sigma is misunderstood in some healthcare organizations, it does not sacrifice clinical quality or cut costs at the expense of patients. Key elements for successful Six Sigma implementation include focusing on patient requirements, designing processes to meet them, measuring performance, involving staff, and using a systematic problem-solving approach with senior management support. Healthcare systems often look outside for experts to initially launch Six Sigma programs and improve integration of new technologies.