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Digital Enterprise Research Institute                                                               www.deri.ie




                     A Semantic Laboratory
                Information Management System
                     for Stem Cell Research
                                               Arindam Halder
                                     P.I. : Helena F Deus, Frank Barry


 Copyright 2011 Digital Enterprise Research Institute. All rights reserved.




                                                                              Enabling Networked Knowledge
Why Stem cells??
Digital Enterprise Research Institute                                www.deri.ie




                                               Enabling Networked Knowledge
The problems for stem
                                cell researcher
Digital Enterprise Research Institute                                www.deri.ie




                                               Enabling Networked Knowledge
Motivation
Digital Enterprise Research Institute                              www.deri.ie




           Long ,complex and expensive experiments

           High failure rates

           Absence of effective data sharing

           Lack of credible in-silico modeling and simulation
            tools.




                                             Enabling Networked Knowledge
Research Hypothesis
Digital Enterprise Research Institute                                www.deri.ie




        To unify public stem cell resources
        To create a plug and play architecture for
         data access
        To enable decision support system.
        To enable agent oriented stem cell modeling
         and simulations.




                                               Enabling Networked Knowledge
Challenges
Digital Enterprise Research Institute                              www.deri.ie



           Data Incoherence
           Data deluge
           Complexity of networks
           Lack of ‘intelligent’ models
           Overlapping phenomena
            representing different
            processes
           To build an agent-based
            stem cell model




                                             Enabling Networked Knowledge
Architecture
Digital Enterprise Research Institute                                          www.deri.ie




                                               Mediated Ontology+
                                               D2RQ Engine
                                    SPARQL
                                    Query



                                             Rule based Multi
   Mechanical                                agent Modelling
   stimulus 1 +                              and simulation



                                                         Enabling Networked Knowledge
Current Status
Digital Enterprise Research Institute                                    www.deri.ie



           Automation of database mapping and ontology creation
                 Mapping STRING database using D2RQ
                 Concept matching between DB and existing appropriate
                  ontologies.




                                                  Enabling Networked Knowledge
Thank You!!!!
Digital Enterprise Research Institute                                 www.deri.ie




                                                Enabling Networked Knowledge

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Slims arindam presentaion

  • 1. Digital Enterprise Research Institute www.deri.ie A Semantic Laboratory Information Management System for Stem Cell Research Arindam Halder P.I. : Helena F Deus, Frank Barry Copyright 2011 Digital Enterprise Research Institute. All rights reserved. Enabling Networked Knowledge
  • 2. Why Stem cells?? Digital Enterprise Research Institute www.deri.ie Enabling Networked Knowledge
  • 3. The problems for stem cell researcher Digital Enterprise Research Institute www.deri.ie Enabling Networked Knowledge
  • 4. Motivation Digital Enterprise Research Institute www.deri.ie  Long ,complex and expensive experiments  High failure rates  Absence of effective data sharing  Lack of credible in-silico modeling and simulation tools. Enabling Networked Knowledge
  • 5. Research Hypothesis Digital Enterprise Research Institute www.deri.ie  To unify public stem cell resources  To create a plug and play architecture for data access  To enable decision support system.  To enable agent oriented stem cell modeling and simulations. Enabling Networked Knowledge
  • 6. Challenges Digital Enterprise Research Institute www.deri.ie  Data Incoherence  Data deluge  Complexity of networks  Lack of ‘intelligent’ models  Overlapping phenomena representing different processes  To build an agent-based stem cell model Enabling Networked Knowledge
  • 7. Architecture Digital Enterprise Research Institute www.deri.ie Mediated Ontology+ D2RQ Engine SPARQL Query Rule based Multi Mechanical agent Modelling stimulus 1 + and simulation Enabling Networked Knowledge
  • 8. Current Status Digital Enterprise Research Institute www.deri.ie  Automation of database mapping and ontology creation  Mapping STRING database using D2RQ  Concept matching between DB and existing appropriate ontologies. Enabling Networked Knowledge
  • 9. Thank You!!!! Digital Enterprise Research Institute www.deri.ie Enabling Networked Knowledge