This issue brief discusses students with disabilities who are at greatest risk of poor employment outcomes after high school. Decades of research show that students with disabilities often have difficulty finding employment after leaving school. The brief aims to identify the specific combinations of risk factors that put students most at risk of unemployment. It will analyze data on these high-risk students to determine what factors are alterable at the school level to improve their post-school employment prospects, such as involvement in vocational education programs or integration with non-disabled peers. The goal is to generate new knowledge that can inform more effective school interventions and strategies to help these high-risk students transition successfully to employment.