Suppositaries

Suppositaries

• 1.
  SUPPOSITARIES Mahesh Gomasa Roll number: 18CE1T0010 BHARAT SCHOOL OF PHARMACY Hyderabad
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  Suppository : These aresolid dosage forms intended for insertion into body cavities or Orifices ( vagina, rectum & urethra) where they melt or get dissolved or exert localized or systematic effect. It comes under semi solid preparations as it is prepared by melting all ingredients like bases and additives along with active ingredients All types of suppositories melt at normal body temperatures after introducing them in body cavity and produce their effect
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  ADVANTAGES : It isalternative dosage form for drugs that have less bioavailability. Drugs having bad odour , taste and irritating effect in GIT can be overcomed by making them as suppositories These are suitable for unconscious, old and infants who find difficult to administer. 1) 2) 3) DISADVANTAGES : Manufacturing processes is difficult as that of other formulations It is stored at low temperatures below (10-20°C) or the bases get liquefied Leakage problem is most crucial problem along with suppositories after introducing at body cavity at elevated temperatures. 1) 2) 3)
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  Add title Add title A d d t i t l e Addtitle Add title METHODS OF PREPARATION Hand Rolling Compression Molding Fusion Molding Automatic Molding Machine
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  • This theoldest and simplest method. • This method is employed for small scale production. HAND ROLLING : 1) The drug is made into powder 3) By Trituration Or kneading 2) Incorporated into suppository base 6) Desired shape is given by hand 5) Rods are cut into pieces 4) Mass is rolled into rod shape by fingers
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  6 4 3 5 COMPRESSION MOLDING: This method follows the same procedure as that of hand molding except the base containing the drug is compressed into suppositories using hand operated machine. Advantages : • It is a simple method skipping the task of hand rolling. • Suppository formed is more elegant than hand molded one. • It avoids possibility of sedimentation of the insoluble solids in the suppository base. Disadvantages : Entrapping of air may occur causing : A)Weight variation. B)Oxidation of drug or base used.
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  FUSION MOLDING : •Thisis the approach exercised on both small and large scale industry due to it's efficacy. •The melted mass of the base containing the drug is pored into suppository molds.
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  3 4 7 Melt thebase completely Cool it to consistency of thick cream Add finely powdered solid drug Stirr untill fully dissolved Proceed in usual way
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  AUTOMATIC MOLDING MACHINE: • This is the modern and automated method for formulation • • The molding function is completely done by machine Typical rotary machine turn out 3500 - 6000 suppositories per hour
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  MOLD : • Omittinghand molding, rest of the methods engage a die for imparting special shape to the mold. • These could be of different shapes
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  Keywords PACKAGING OF SUPPOSITORIES &STORAGE : Suppositoriesare usually packed in shallow partitioned card board boxes which can hold them in upright position and do not allow them to come in contact with each other. Many commercial suppositories are packed separately in aluminum foil or PVC Polythene strip. • •
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  Glycero - gelatinsuppositories are often packed in tightly closed screw capped glassglass container. • Nowadays , Suppositories are directly moulded into primary packaging made of plastic material or aluminum foils • • The moulds are seeled and the excess is trimmed off and finally packed in cartons.
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  Add your text Addyour text Add your title Add your text STORAGE CONDITIONS : The suppositories are required to be stored in a cold place so that they can retain their shape at the room temperature. These are stored at temperatures below 35°F or can be stored at controlled room temperature of 20-25° C
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