4
Most read
5
Most read
8
Most read
Dr.V. S. Swathi
Assistant Professor
 Syphilis is caused by the spirochete
Treponema pallidum and is characterised by
three sequential clinical, symptomatic
stages separated by periods of
asymptomatic latent infections.
 Each year, there are an estimated 6 million
new cases of syphilis globally in persons
aged 15-49 years
 In 2015, syphilis cases found in India were
30,000 approximately
PrimarySyphilis
 It appears after 10-90 days of infection
 one or more small painless sores appears in or around the genitals,
anus and mouth
Secondary Syphilis
 It appears 2-8 weeks after infection
 It affects circulatory and lymphatic system
Latent Syphilis
 It appears after 4-10 weeks after infection
 In this stage patient does not show any symptoms
 Microbes will spread all over the body
Tertiary Syphilis
 It appears after 10-30 years after infection
 In this stage brain, heart, eyes, bones and joints are affected
 Persons having unprotected sex
 HIV patients
 Persons with multiple sex partners
 Unborn babies of mothers who are having
Syphilis
 It is caused by bacterium called Treponema
pallidum
 It is mostly transmitted by sexual
intercourse with affected patients with
Syphilis
 It can also transmitted to baby by mother
with Syphilis
 Occasionally it is transmitted through
contact with lesions of infected patients
and through blood transfusions
Syphilis
Syphilis
Primary Syphilis
 Chancres on skin
Secondary Syphilis
 Number of mucocutaneous eruptions
 Malaise
 Fever
 Pharyngitis
 Headache
 Anorexia
 Arthralgia
Latent Syphilis- Asymptomatic
Tertiary Syphilis:
Neurosyphilis
 Severe headache
 Difficulty in coordinating muscle movements
 Paralysis
 Numbness
 Dementia
Ocular Syphilis
 Blurred division
 Blindness
 Neurosyphilis
 Ocular syphilis
 Cardiovascular syphilis
 Congenital syphilis
 Joint/ bone syphilis
 Microscopic examination of serous material
from a suspected syphilis lesion
 Direct fluorescent antibody test for
Treponema pallidum (DFA-TP)
 Venereal disease research laboratory test
(VDRL) slide test
 Rapid plasma regain (RPR) card test
 Unheated serum reagin (USR) test
 Toludene red unheated serum test (TRUST)
 PCR test
Syphilis
 Counselling to avoid unprotected sex,
having multiple sex partners
 Take proper measures to keep environment
hygienic
Syphilis
Drug Category Mode of action Dose Adverse effects
Benzathine
Penicillin G
Penicillin Inhibit bacterial
cell wall
synthesis
2.4 million
units once
weekly- IM
 Skin rashes
 Urticaria
 Serum sickness reactions
 Jarisch- Harxheimer
reaction
 Pseudomembranous colitis
Aqueous
procaine
penicillin
Penicillin Inhibit bacterial
cell wall
synthesis
2.4 million
units once
daily- IM
for 10-14
days with
Probenacid
 Skin rashes
 Urticaria
 Serum sickness reactions
 Jarisch- Harxheimer
reaction
 Pseudomembranous colitis
Aqueous
crystalline
penicillin
Penicillin Inhibit bacterial
cell wall
synthesis
18-24
million
units once
daily- IM
for 10-14
days
 Seizures
 Anaemia
 Interstitial nephritis
 Jarisch- Harxheimer
reaction
 Hypersensitivity
Ceftrioxone Cephalosporin Inhibit bacterial
cell wall synthesis
1-2g-IM/ IV
four times for
28 days
 Eosinophilia
 Thrombocytosis
 Diarrhoea
 Hepatotoxicity
 Nephrotoxicity
Tetracycline Tetracycline Inhibit bacterial
protein synthesis
500mg- four
times orally
for 14-28 days
 Epigastric distress
 Teeth discoloration
 Photosensitivity
 Nephrotoxicity
 Hepatotoxicity
Doxycycline Tetracycline Inhibit bacterial
protein synthesis
100mg-twice
daily for 14
days
 Anorexia
 Tooth discoloration
 Diarrhoea
 Dysphagia
 Enterocolitis
Probenacid Uricosuric agent Along with
penicillin it
increases penicillin
levels in body by
inhibiting tubular
secretion of
penicillin
500mg- four
times- orally
for 10-14 days
along with Aq.
Procaine
Penicillin
 Anaemia
 Leucopoenia
 Renal calculi
 Exacerbation of gout
 Gouty Arthralgia
 https://www.ncbi.nlm.nih.gov/pmc/articles
/PMC5434955/
 http://www.neurologyindia.com/text.asp?
2016/64/7/131/178060
 http://www.ijmm.org/text.asp?2016/34/1/1
11/167674
 https://doi.org/10.1016/j.ijgo.2015.04.014
 https://www.ncbi.nlm.nih.gov/pmc/articles
/PMC4386224/

More Related Content

PPTX
PPTX
Stages of syphilis and its treatment
PPTX
Gonorrhea
PPTX
Syphilis lecture PP
PPTX
Syphilis PPT
PPTX
PPTX
SYPHILIS & GONORRHOEA
Stages of syphilis and its treatment
Gonorrhea
Syphilis lecture PP
Syphilis PPT
SYPHILIS & GONORRHOEA

What's hot (20)

PPTX
BRONCHIAL ASTHMA
PPTX
PPTX
Megaloblastic anemia
PPTX
MALARIA.pptx
PPTX
Diptheria
PPTX
Status asthmaticus
PPTX
Pneumonia
PPTX
AMYLOIDOSIS
PPTX
HIV INFECTION
PPTX
Patho inflammation
PPTX
Syphilis
PPT
Bacillary dysentery (shigellosis
PPTX
Cirrhosis of liver
PPTX
PPTX
Gout ppt
PPTX
Meningitis
PPTX
Tuberculosis
BRONCHIAL ASTHMA
Megaloblastic anemia
MALARIA.pptx
Diptheria
Status asthmaticus
Pneumonia
AMYLOIDOSIS
HIV INFECTION
Patho inflammation
Syphilis
Bacillary dysentery (shigellosis
Cirrhosis of liver
Gout ppt
Meningitis
Tuberculosis
Ad

Similar to Syphilis (20)

PPTX
Syphilis BMS internal medicine PowerPoint presentation
PPTX
Syphilis ppt - .pptx
PPTX
syphillis.pptx
PPT
Syphilis in a nutshell
PDF
Syphilis
PPT
Syphilis
PDF
SYPHILIS.pdf
PPTX
Copy of 23.Sexually transmitted infeztion disease.pptx
PPTX
Sexually transmitted disease(SYPHILIS)
PPTX
Syphilis 2 .pptx .
PPTX
Syphilis -community pharmacy
PPTX
06. SYPHILIS.pptx
PPTX
Syphilis
PDF
syphilisnibi hEALTH CARE RELATED TOPICS.pdf
PPTX
Syphilis
PPT
Russell Waddell: Syphilis Presentation and Treatment
PDF
Urticariform Lesions as a Manifestation of Secondary Syphilis: Case Report
PDF
Urticariform Lesions as a Manifestation of Secondary Syphilis: Case Report
PPTX
11-Sexually transmitted disease (2).pptx
PPTX
$$ SYPHILIS $$
Syphilis BMS internal medicine PowerPoint presentation
Syphilis ppt - .pptx
syphillis.pptx
Syphilis in a nutshell
Syphilis
Syphilis
SYPHILIS.pdf
Copy of 23.Sexually transmitted infeztion disease.pptx
Sexually transmitted disease(SYPHILIS)
Syphilis 2 .pptx .
Syphilis -community pharmacy
06. SYPHILIS.pptx
Syphilis
syphilisnibi hEALTH CARE RELATED TOPICS.pdf
Syphilis
Russell Waddell: Syphilis Presentation and Treatment
Urticariform Lesions as a Manifestation of Secondary Syphilis: Case Report
Urticariform Lesions as a Manifestation of Secondary Syphilis: Case Report
11-Sexually transmitted disease (2).pptx
$$ SYPHILIS $$
Ad

More from swathisravani (20)

PPTX
Chemotherapy induced nausea and vomiting
PPTX
Leukaemia
PPTX
Breast cancer
PPTX
Chemotherapy agents
PPTX
Basic principles of cancer chemotherapy
PPTX
Scabies
PPTX
Impetigo
PPTX
Eczema or Dermatitis
PPTX
Psoriasis
PPTX
Renal dialysis
PPTX
Drug induced kidney disease
PPTX
Chronic Renal Failure
PPTX
Acute Renal Failure
PPTX
SYSTEMIC LUPUS ERYTHEMATOSUS
PPTX
Ankylosing Spondylitits
PPTX
PPTX
Osteoarthritis
PPTX
Rheumatoid arthritis
PPTX
Viral hepatitis
PPTX
Malaria
Chemotherapy induced nausea and vomiting
Leukaemia
Breast cancer
Chemotherapy agents
Basic principles of cancer chemotherapy
Scabies
Impetigo
Eczema or Dermatitis
Psoriasis
Renal dialysis
Drug induced kidney disease
Chronic Renal Failure
Acute Renal Failure
SYSTEMIC LUPUS ERYTHEMATOSUS
Ankylosing Spondylitits
Osteoarthritis
Rheumatoid arthritis
Viral hepatitis
Malaria

Recently uploaded (20)

PPTX
Critical Issues in Periodontal Research- An overview
PPTX
01. cell injury-2018_11_19 -student copy.pptx
PPTX
Computed Tomography: Hardware and Instrumentation
PPTX
Geriatrics_(0).pptxxvvbbbbbbbnnnnnnnnnnk
PPTX
Applied anatomy and physiology of Esophagus .pptx
PDF
Nematodes - by Sanjan PV 20-52.pdf based on all aspects
PPTX
AWMI case presentation ppt AWMI case presentation ppt
PPT
fiscal planning in nursing and administration
PDF
495958952-Techno-Obstetric-sminiOSCE.pdf
PDF
periodontaldiseasesandtreatments-200626195738.pdf
PPTX
This book is about some common childhood
PDF
Gonadotropin-releasing hormone agonist versus HCG for oocyte triggering in an...
PPTX
SUMMARY OF EAR, NOSE AND THROAT DISORDERS INCLUDING DEFINITION, CAUSES, CLINI...
PPTX
ACUTE PANCREATITIS combined.pptx.pptx in kids
PPTX
SEMINAR 6 DRUGS .pptxgeneral pharmacology
PPTX
Journal Article Review - Ankolysing Spondylitis - Dr Manasa.pptx
PPTX
sexual offense(1).pptx download pptx ...
PPTX
Biostatistics Lecture Notes_Dadason.pptx
PDF
heliotherapy- types and advantages procedure
PPTX
Approach to Abdominal trauma Gemme(COMMENT).pptx
Critical Issues in Periodontal Research- An overview
01. cell injury-2018_11_19 -student copy.pptx
Computed Tomography: Hardware and Instrumentation
Geriatrics_(0).pptxxvvbbbbbbbnnnnnnnnnnk
Applied anatomy and physiology of Esophagus .pptx
Nematodes - by Sanjan PV 20-52.pdf based on all aspects
AWMI case presentation ppt AWMI case presentation ppt
fiscal planning in nursing and administration
495958952-Techno-Obstetric-sminiOSCE.pdf
periodontaldiseasesandtreatments-200626195738.pdf
This book is about some common childhood
Gonadotropin-releasing hormone agonist versus HCG for oocyte triggering in an...
SUMMARY OF EAR, NOSE AND THROAT DISORDERS INCLUDING DEFINITION, CAUSES, CLINI...
ACUTE PANCREATITIS combined.pptx.pptx in kids
SEMINAR 6 DRUGS .pptxgeneral pharmacology
Journal Article Review - Ankolysing Spondylitis - Dr Manasa.pptx
sexual offense(1).pptx download pptx ...
Biostatistics Lecture Notes_Dadason.pptx
heliotherapy- types and advantages procedure
Approach to Abdominal trauma Gemme(COMMENT).pptx

Syphilis

  • 2.  Syphilis is caused by the spirochete Treponema pallidum and is characterised by three sequential clinical, symptomatic stages separated by periods of asymptomatic latent infections.
  • 3.  Each year, there are an estimated 6 million new cases of syphilis globally in persons aged 15-49 years  In 2015, syphilis cases found in India were 30,000 approximately
  • 4. PrimarySyphilis  It appears after 10-90 days of infection  one or more small painless sores appears in or around the genitals, anus and mouth Secondary Syphilis  It appears 2-8 weeks after infection  It affects circulatory and lymphatic system Latent Syphilis  It appears after 4-10 weeks after infection  In this stage patient does not show any symptoms  Microbes will spread all over the body Tertiary Syphilis  It appears after 10-30 years after infection  In this stage brain, heart, eyes, bones and joints are affected
  • 5.  Persons having unprotected sex  HIV patients  Persons with multiple sex partners  Unborn babies of mothers who are having Syphilis
  • 6.  It is caused by bacterium called Treponema pallidum  It is mostly transmitted by sexual intercourse with affected patients with Syphilis  It can also transmitted to baby by mother with Syphilis  Occasionally it is transmitted through contact with lesions of infected patients and through blood transfusions
  • 9. Primary Syphilis  Chancres on skin Secondary Syphilis  Number of mucocutaneous eruptions  Malaise  Fever  Pharyngitis  Headache  Anorexia  Arthralgia
  • 10. Latent Syphilis- Asymptomatic Tertiary Syphilis: Neurosyphilis  Severe headache  Difficulty in coordinating muscle movements  Paralysis  Numbness  Dementia Ocular Syphilis  Blurred division  Blindness
  • 11.  Neurosyphilis  Ocular syphilis  Cardiovascular syphilis  Congenital syphilis  Joint/ bone syphilis
  • 12.  Microscopic examination of serous material from a suspected syphilis lesion  Direct fluorescent antibody test for Treponema pallidum (DFA-TP)  Venereal disease research laboratory test (VDRL) slide test  Rapid plasma regain (RPR) card test  Unheated serum reagin (USR) test  Toludene red unheated serum test (TRUST)  PCR test
  • 14.  Counselling to avoid unprotected sex, having multiple sex partners  Take proper measures to keep environment hygienic
  • 16. Drug Category Mode of action Dose Adverse effects Benzathine Penicillin G Penicillin Inhibit bacterial cell wall synthesis 2.4 million units once weekly- IM  Skin rashes  Urticaria  Serum sickness reactions  Jarisch- Harxheimer reaction  Pseudomembranous colitis Aqueous procaine penicillin Penicillin Inhibit bacterial cell wall synthesis 2.4 million units once daily- IM for 10-14 days with Probenacid  Skin rashes  Urticaria  Serum sickness reactions  Jarisch- Harxheimer reaction  Pseudomembranous colitis Aqueous crystalline penicillin Penicillin Inhibit bacterial cell wall synthesis 18-24 million units once daily- IM for 10-14 days  Seizures  Anaemia  Interstitial nephritis  Jarisch- Harxheimer reaction  Hypersensitivity
  • 17. Ceftrioxone Cephalosporin Inhibit bacterial cell wall synthesis 1-2g-IM/ IV four times for 28 days  Eosinophilia  Thrombocytosis  Diarrhoea  Hepatotoxicity  Nephrotoxicity Tetracycline Tetracycline Inhibit bacterial protein synthesis 500mg- four times orally for 14-28 days  Epigastric distress  Teeth discoloration  Photosensitivity  Nephrotoxicity  Hepatotoxicity Doxycycline Tetracycline Inhibit bacterial protein synthesis 100mg-twice daily for 14 days  Anorexia  Tooth discoloration  Diarrhoea  Dysphagia  Enterocolitis Probenacid Uricosuric agent Along with penicillin it increases penicillin levels in body by inhibiting tubular secretion of penicillin 500mg- four times- orally for 10-14 days along with Aq. Procaine Penicillin  Anaemia  Leucopoenia  Renal calculi  Exacerbation of gout  Gouty Arthralgia
  • 18.  https://www.ncbi.nlm.nih.gov/pmc/articles /PMC5434955/  http://www.neurologyindia.com/text.asp? 2016/64/7/131/178060  http://www.ijmm.org/text.asp?2016/34/1/1 11/167674  https://doi.org/10.1016/j.ijgo.2015.04.014  https://www.ncbi.nlm.nih.gov/pmc/articles /PMC4386224/