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The document discusses the functional properties of Bacillus coagulans, a thermostable lactic acid-forming probiotic bacteria. B. coagulans spores can survive the harsh conditions of the stomach and intestinal tract. It can settle in the digestive tract and produce lactic acid and other substances that inhibit pathogenic bacteria. Studies also suggest B. coagulans may have immune-modulating effects and help regulate blood sugar and lipid levels. Due to its heat resistance and health benefits, B. coagulans is seen as a promising probiotic for supporting gut and overall health.
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- 1. presents Functional propertiesof Thermostable lactic acid- forming bacteria (B. coagulans) Dr. Maryam Tajabadi Ebrahimi Iranian Society of Probiotic and Functional Food
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- 3. 1014 micro-organisms, >400differentes species stomach Jejunum Ileum Colon with appendix Duodenum 102 to 103 <105 104 to 107 109 to 1012 Lactobacilli Streptococci Lactobacilli Enterobacteria Enterococcus Faesalis Bacteroides Bifidobacteria Peptococcus Raminococcus Clostridia Lactobacilli 3 Takgene BC Takgene.com
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- 6. 2. Moreover, wealso consume antibacterial substances ranging from vinegar to antibiotics 1. The changing food habits and lifestyle force us to take processed and sterile food, which affects our access to, and colonization, by certain type of bacteria. 6 Takgene BC Takgene.com
- 7. 400+ Species ofPrpbiotics In Your Body 7
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- 9. 9 “Death sitsin the bowels; a bad digestion is the root of all evil” - Hippocrates, ca. 400 BC Takgene BC Takgene.com First described by Metchnikoff in 1908“Live microbial food ingredients that alter the microflora and confer health benefit” WHO definition(2001): “Live micro-organisms which, when administered in adequate amounts, confer a health benefit on the host”
- 10. 0 10 20 30 40 50 60 70 2004 2005 2006 2007 2008 2009 Probiotic Prebiotic 0 200 400 600 800 1000 1200 1400 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 Number of publications/year Awareness of the terms are moving into "mainstream"… with 3 of 5 consumers now aware of the term probiotics 10 Takgene BC Takgene.com
- 11. Probiotic Supplements 11 Takgene BC Takgene.com Probiotic Functional foods
- 12. Dairy Non-Dairy 12 Takgene BC Takgene.com
- 13. Dairy 38% Bakery&cereal23% Beverage 12% Meat, Fish&egg 7% Soya Products 6% Fat& Oil 8% Other 6% 13 Takgene BC Takgene.com
- 14. L. sporogenes (Bacilluscoagulance) Contain a large number of viable lactobacilli that retain viability during preparation in pharmaceutical dosage forms and during storage before consumption. The spores are thermostable as against viable L. acidophilus cells which may not withstand spray drying. Survive in gastric secretions and bile of the upper digestive tract and reach the intestine safely. Settle in the digestive tract and produce enough lactic acid and other antagonistic substances to inhibit the growth of pathogenic bacteria. 14 Takgene BC Takgene.com
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- 17. Bacillus coagulans hasbeen added by the EFSA to their Qualified Presumption of Safety list approved for as GRAS by the U.S. Food and Drug Administration's Center 17 Takgene BC Takgene.com
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- 20. •Maturation of mononuclearphagocytes toward both macrophage and dendritic cell •T helper cell differentiation •Generating T regulatory cells •Cell wall & metabolites modulate inflammatory processes •Induction of IL-10, •Possible treatment of inflammatory bowel diseases •Adjunct therapy for relieving symptoms of rheumatoid arthrite Bebsons et al. World J Gastroenterol 2012 April 28; 18(16): 1875-1883 Mandel et al. BMC Complementary and Alternative Medicine 2010, 10:1 Jensen et al. BMC Immunology 2010, 11:15 20 Takgene BC Takgene.com
- 21. •Improve bowel movement •Defecation frequency •Increase number of intestinal bifdobacteria •Decrease intestinal clostridium perfringens •Improvements in GSRS abdominal pain •Concentrations of intestinal ammonia, indole and p-cresol decreased •Improved abdominal pain and bloating in patients with IBS Phalguni Dutta et al. Tropical Medicine and International Health Kal man et al., BMC Gastroenterology 2009 Larysa Hun et al., Postgraduate Medicine, 2009 Katsutoshi Ara, et al., 2002, Microbial Ecology in Health and Disease 21 Takgene BC Takgene.com
- 22. •Decrease in seruminsulin levels •hs-crp, •Uric acid •Reduces levels of lipid profile •Increase of glutathione •Increase of TAC Z. Asemi et al., Clinical Nutrition, 2013 Z. Asemi et al., Lipid, 2013 Shakeri et al., Lipid, 2014 Tajabadi Ebrahimi et al., 2014, Ann Nutr Metab 22 Takgene BC Takgene.com
- 23. •Screening for Aflatoxinbinding •Alanin transferase (ALT) •Aspartat aminotransferase (AST) •Alkalin transferase (ALP) 23 Control Aflatoxin B1 Aflatoxin B1+ B. Coagulance Takgene BC Takgene.com
- 24. 24 •Take careof microbiota •Probiotic can improve healthy microbiota •B. coagulance is heat resistant probiotic - Immune modulation - Metabolic status in diabetic patients - Gut health Takgene BC Takgene.com
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- 26. (Dr. Michael L.McCann) “Probiotics will be medicine in the 21st century what antibiotics and microbiology were in the 20th” 26 Takgene BC Takgene.com