Targeted Drug Delivery System Using Nano Technology . Birbhum pharmacy school doi10.5281/zenodo.15974987 https://www.ijpsjournal.com/article/Targeted%20Drug%20Delivery%20System%20Using%20Nano%20Technology

Targeted Drug Delivery System Using Nano Technology . Birbhum pharmacy school doi10.5281/zenodo.15974987 https://www.ijpsjournal.com/article/Targeted%20Drug%20Delivery%20System%20Using%20Nano%20Technology

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  TARGETED DRUG DELIVERY SYSTEMUSING NANOTECHNOLOGY PRESENTED BY NAME: SYED MAHFUZ ISLAM ROLL: 35301921051 REG: 213530201910053 OF 2021-22 STUDENT OF BIRBHUM PHARMACY SCHOOL BANDHERSOLE, BIRBHUM , W.B - 731124 UNDER THE GUIDANCE OF MR. RAKESH MANNA PROJECT SUPERVISOR ASSISTANT PROFESSIOR DEPARTMENT OF PHARMACOLOGY MRS. SANJUKTA DAS PROJECT CO- SUPERVISOR ASSISTANT PROFESSIOR DEPARTMENT OF PHARMACOLOGY
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  CONTENTS TOPIC PAGE NO. INTRODUCTION1 BASICS OF NANOTECHNOLOGY 2 MECHANISMS OF TARGETED DRUG DELIVERY 3 TYPES OF NANOPARTICLES USED 4 ADVANTEGES OF TARGETED DRUG DELIVERY 5 CHALLENGES IN TARGETED DRUG DELIVERY 6 RECENT ADVANCES IN THE FIELD 7 APPLICATIONS IN CANCER THERAPY 8 NANOMEDICINES IN DIABETES MANAGEMENT 9 NANOMEDICINES IN CARDIOVASCULAR DISEASES 10 FUTURE PERSPECTIVES 11 CONCLUSION 12 REFERENCES 13
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  • Targeted drugdelivery systems are designed to deliver medication directly to specific cells or tissues. • This approach minimizes side effects and enhances therapeutic efficacy. • Nanotechnology plays a crucial role in improving the precision of drug delivery systems. INTRODUCTION FIG: 1.1 Page 1
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   Basics ofNanotechnology  Nanotechnology involves manipulating matter at the nanoscale, typically between 1 and 100 nanometers.  At this scale, materials often exhibit unique physical and chemical properties.  These properties make nanoparticles ideal carriers for drugs, enabling improved targeting and release profiles. Page 2 FIG: 2.1
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   Mechanisms ofTargeted Drug Delivery  Targeted drug delivery can be achieved through passive and active targeting mechanisms.  Passive targeting relies on the enhanced permeability and retention (EPR) effect in tumors.  Active targeting utilizes ligands on nanoparticles that specifically bind to receptors on target cells. Page 3 FIG: 3.1
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   Types ofNanoparticles Used  Common types of nanoparticles include liposomes, solid lipid nanoparticles, and polymeric nanoparticles.  Each type has distinct advantages based on stability, drug loading capacity, and release mechanisms.  The choice of nanoparticle depends on the drug properties and targeted disease type. Page 4 FIG: 4.1
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   Advantages ofTargeted Drug Delivery  Lower Toxic Effects - Targeted drug delivery can significantly reduce systemic toxicity by confining drug action to specific sites.  Improved Efficacy - This approach enhances drug concentration at the target site, potentially improving therapeutic outcomes.  Lower Drug Dosage - It also allows for lower dosages, which can reduce costs and improve patient compliance. Page 5 Enhanced Precision – Nano particles can deliver drugs directly to diseased cells, minimizing damage to healthy tissues. Personalized Medicine - Nanotech enables customized treatments based on individual patient needs. Minimized Drug Resistance - Targeted delivery reduces the chances of pathogens developing resistance to treatment.
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   Challenges inTargeted Drug Delivery  Biocompatibility Issues - Some nano particles may trigger immune responses or toxicity in the body.  Complex Manufacturing - Producing nano carriers with precise properties is expensive and technically demanding.  Stability Concerns – Nano particles may degrade or lose effectiveness before reaching their target.  Limited Drug Loading Capacity - Some nano carriers struggle to hold sufficient drug amounts for effective treatment. Page 6
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   Recent Advancesin the Field  Ocular Drug Delivery Systems - Nanotechnology is improving treatments for eye diseases like glaucoma and diabetic retinopathy by enhancing drug absorption and reducing side effects.  Cancer Treatment Innovations - Researchers are developing nano particle-based delivery systems for natural medicines, improving their targeting ability and effectiveness against tumors.  Smart Nanomaterials - Advanced nano materials are being designed to enhance drug stability, solubility, and controlled release, making treatments more efficient.  Personalized Nanomedicine - Scientists are exploring customized drug delivery solutions tailored to individual patient needs, increasing treatment precision. Page 7 FIG: 7.1
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   Applications inCancer Therapy Page 8 FIG: 8.1 Nanotechnology has remodeling cancer therapy, offering innovative solutions for diagnosis and treatment. Targeted Drug Delivery: Nano particles can deliver chemotherapy drugs directly to cancer cells, minimizing damage to healthy tissues. Photothermal Therapy: Gold nano particles can absorb light and generate heat, selectively destroying cancer cells. Gene Therapy: Nano carriers help deliver genetic material to modify or suppress cancer-causing genes. Nano-enabled Immunotherapy: Nanoparticles enhance immune system responses against tumors, improving treatment effectiveness.
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   Nanomedicines InDiabetes Management Smart Insulin Delivery: Nanoparticles enable controlled and sustained insulin release, reducing the need for frequent injections. Glucose-Sensitive Nanocarriers: These carriers respond to blood sugar levels, releasing insulin only when needed. Nanosensors for Monitoring: Advanced nanosensors provide real-time glucose monitoring, improving accuracy and convenience. Regenerative Medicine: Nanotechnology aids in pancreatic cell regeneration, offering potential long-term solutions for diabetes treatment. FIG: 9.1 Page 9
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   Nanomedicines InCardiovascular Diseases Page 10 Targeted Drug Delivery: Nanoparticles enhance precision in delivering medications to affected heart tissues, reducing side effects. Anti-inflammatory Treatments: Nanomedicines help reduce inflammation in blood vessels, lowering the risk of heart disease. Atherosclerosis Treatment: Nanoparticles can target and break down arterial plaques, reducing the risk of heart attacks. Nano-enabled Stents: Coated stents with nanomaterials enhance biocompatibility and reduce the risk of restenosis (artery narrowing after treatment). FIG: 10.1
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   Future Perspectives Page11 FIG: 11.1 Personalized Nanomedicine Advances in genomics and proteomics will help tailor nanocarriers to individual patient profiles. Integrated Theranostic Platforms The evolution of theranostics—where diagnostic and therapeutic functions are combined into a single nanosystem—will enable real-time monitoring of drug delivery and treatment responses. Remote-Controlled and External Triggered Release Building on current innovations, upcoming strategies might include nanocarriers that can be remotely controlled. Artificial Intelligence-Driven Design Integrating AI and machine learning can remodeling nanoparticle design. By analyzing large datasets from clinical trials and laboratory experiments, AI can help optimize particle size, surface charge, and drug-loading efficiency, greatly accelerating the discovery-to-market process for innovative nanomedicines.
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   Conclusion Page 12 Nanotechnology-basedtargeted drug delivery is remodeling modern medicine by enhancing the precision, efficiency, and safety of therapeutic interventions. By utilizing nanoparticles to selectively target diseased cells, this approach minimizes systemic side effects while maximizing treatment efficacy. Its applications span a wide range of medical fields, including cancer therapy, cardiovascular treatments, and infectious disease control. As research progresses, nanotechnology-based drug delivery stands poised to redefine healthcare, offering more effective, less aggressive, and highly modify treatment solutions for patients worldwide.
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  Page 13  References •SuriSS, Fenniri H, Singh B. Nanotechnology-based drug delivery systems. Journal of Occupational Medicine and Toxicology 2007;2:16. https://doi.org/10.1186/1745-6673-2-16. •Koo OM, Rubinstein I, Onyuksel H. Role of nanotechnology in targeted drug delivery and imaging: a concise review. Nanomedicine: Nanotechnology, Biology and Medicine 2005;1:193–212. https://doi.org/10.1016/j.nano.2005.06.004. •Eker F, Duman H, Akdaşçi E, et al. A Comprehensive Review of Nanoparticles: From Classification to Application and Toxicity. Molecules 2024;29:3482. https://doi.org/10.3390/molecules29153482. •Singh AP, Biswas A, Shukla A, et al. Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles. Sig Transduct Target Ther 2019;4:1–21. https://doi.org/10.1038/s41392-019-0068-3. •Martín Giménez VM, Kassuha DE, Manucha W. Nanomedicine applied to cardiovascular diseases: latest developments. Therapeutic Advances in Cardiovascular Disease 2017;11:133–42. https://doi.org/10.1177/1753944717692293. •Patra JK, Das G, Fraceto LF, et al. Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol 2018;16:71. https://doi.org/10.1186/s12951-018-0392-8.