Tarsal tunnel syndrome is a compression neuropathy of the posterior tibial nerve as it passes through the tarsal tunnel. It commonly affects middle-aged females and causes pain, burning, and numbness on the inside of the ankle and bottom of the foot. Diagnosis involves clinical tests like Tinel's sign and imaging like MRI. Treatment begins conservatively with rest, medications, splinting and nerve glides, while surgery to decompress the nerve may be needed in some cases.