The document outlines the theoretical, conceptual, and methodological framework for a meta-synthesis of 18 studies on the adoption and impact of open educational practices and resources in the Global South conducted as part of the Research on Open Educational Resources for Development project. The framework analyzes educational challenges, contextual factors, agents, open educational practices and resources used, the impact of adoption, and the degree of social transformation across studies in South America, Sub-Saharan Africa, and South and Southeast Asia. The goal is to integrate insights from the individual studies into a higher-order synthesis.