This document reports on efforts investigating videoconferencing and collaboration technologies at the Lister Hill National Center for Biomedical Communications. It describes the Collaboratory setting where this work takes place and reviews research on using videoconferencing in telemedicine and distance education. Specific videoconferencing and collaboration tools currently used in the Collaboratory are outlined. Observations from experimenting with these technologies are presented and future work is proposed at the theoretical, programmatic, and technical levels.