The document summarizes the state of endpoint threats and defenses in 2021. It finds that while Windows PCs remain a top target, Mac malware is growing. Ransomware increased dramatically over the past year and remains a major threat. Endpoint defenses are still fragmented across antivirus, next-gen antivirus, EDR, and other tools. The document recommends strategies like hardening systems, adopting a zero trust model, training incident response teams, and regularly testing defenses to combat evolving endpoint threats.