Bryan Cantrill discusses the evolution of computing systems from holistic designs to fragmented ones due to shifts in hardware and software compatibility, particularly highlighting issues with BIOS, UEFI, and proprietary software barriers. Oxide Computer Company aims to create a new, integrated server-side computing system using their unique approach, which includes a custom open-source operating system and holistic booting methods. The push for holistic systems promises improved reliability and security, while also calling for better documentation from microprocessor vendors to facilitate development.