This travel guide provides information for visiting major cities in Italy between 1400-1500, including Florence, Rome, and Venice. It recommends seeing landmarks like the Duomo in Florence, the Colosseum and Vatican in Rome, and St. Mark's Basilica in Venice. For transportation, walking, horses, and boats are suggested depending on the city. The guide outlines local customs like greeting with kisses and manners around food. It provides options for lodging from wealthy homes to inns. Entertainment includes music, dancing, and art/architecture. Health risks like the bubonic plague are also covered.