UPDATE on MALARIA
VACCINE
MALARIA VACCINE
 The only approved vaccine, as of 2021, is RTS,S, known by the
brand name Mosquirix.
 It requires four injections.
 Research continues with other malaria vaccines. The most effective
malaria vaccine is R21/Matrix-M, with a 77% efficacy rate shown in
initial trials and significantly higher antibody levels than with the
RTS,S vaccine.
 It is the first vaccine that meets the World Health Organization’s
(WHO) goal of a malaria vaccine with at least 75% efficacy.
VACCINE TYPE :- protein subunit
UPDATE  on  NEWER  MALARIA  VACCINE.pptx
RTS VACCINE
 It consists of the P. falciparum circumsporozoite protein (CSP) from
the pre-erythrocytic stage.
 The CSP antigen causes the production of antibodies capable of
preventing the invasion of hepatocytes and additionally elicits a
cellular response enabling the destruction of infected hepatocytes.
 In October 2021, the vaccine was endorsed by the World Health
Organization for "broad use" in children, making it the first malaria vaccine
to receive this recommendation.
 SCEHUDULE : 3 doses initial series with a min interval of 4 wks btw doses
followed by 4th dose at 15- 18 month after 3rd dose is
recommended
 The first dose should be administered as close as possible to age of 5th
month and 3rd
dose should be completed by 9 month of age .
HPV VACCINE
Two HPV vaccines are licensed by the FDA and recommended by
CDC. These vaccines are Cervarix (made by GlaxoSmithKline) and
Gardasil (made by Merck).
Both vaccines are very effective against HPV types 16 and 18,
which cause most cervical cancers.
So both vaccines prevent cervical cancer in women.
Both vaccines are very safe. Both vaccines are made with very
small parts of the human papillomavirus (HPV) that cannot cause
infection
Only one of the vaccines (Gardasil) protects against HPV types 6 and 11
These types can cause most genital warts in females and males.
Only one of the vaccines (Gardasil) has been tested and licensed for use in
males.
IAP recommends that all girls who are 11 or 12 years old get the 2 doses
6 months apart of either brand of HPV vaccine to protect against cervical cancer.
Gardasil also protects against most genital warts, as well as some cancers
of the vulva, vagina, and anus.
Girls and young women ages 14 years or older should get 3 doses of an HPV
vaccine(garasil) at 0, 2 & 6 months & for cervarix at 0,1 & 6 months if they have
not received all doses yet.
 Gardasil also protects against most genital warts, as well as some
cancers of the vulva, vagina, and anus.
 Girls and young women ages 14 years or older should get 3 doses
of an HPV vaccine(gardasil) at 0, 2 & 6 months & for cervarix at 0,1
& 6 months if they have not received all doses yet.
• Newer vaccines for HPV is gardasil 9 and cervavac
• Gardasil 9 protects against 9 serotypes[6,11,16,18,31,33,45,52,58] and
cervavac protects against 4 serotypes [6,11,16,18].

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UPDATE on NEWER MALARIA VACCINE.pptx

  • 2. MALARIA VACCINE  The only approved vaccine, as of 2021, is RTS,S, known by the brand name Mosquirix.  It requires four injections.  Research continues with other malaria vaccines. The most effective malaria vaccine is R21/Matrix-M, with a 77% efficacy rate shown in initial trials and significantly higher antibody levels than with the RTS,S vaccine.  It is the first vaccine that meets the World Health Organization’s (WHO) goal of a malaria vaccine with at least 75% efficacy. VACCINE TYPE :- protein subunit
  • 4. RTS VACCINE  It consists of the P. falciparum circumsporozoite protein (CSP) from the pre-erythrocytic stage.  The CSP antigen causes the production of antibodies capable of preventing the invasion of hepatocytes and additionally elicits a cellular response enabling the destruction of infected hepatocytes.
  • 5.  In October 2021, the vaccine was endorsed by the World Health Organization for "broad use" in children, making it the first malaria vaccine to receive this recommendation.  SCEHUDULE : 3 doses initial series with a min interval of 4 wks btw doses followed by 4th dose at 15- 18 month after 3rd dose is recommended  The first dose should be administered as close as possible to age of 5th month and 3rd dose should be completed by 9 month of age .
  • 6. HPV VACCINE Two HPV vaccines are licensed by the FDA and recommended by CDC. These vaccines are Cervarix (made by GlaxoSmithKline) and Gardasil (made by Merck). Both vaccines are very effective against HPV types 16 and 18, which cause most cervical cancers. So both vaccines prevent cervical cancer in women. Both vaccines are very safe. Both vaccines are made with very small parts of the human papillomavirus (HPV) that cannot cause infection
  • 7. Only one of the vaccines (Gardasil) protects against HPV types 6 and 11 These types can cause most genital warts in females and males. Only one of the vaccines (Gardasil) has been tested and licensed for use in males. IAP recommends that all girls who are 11 or 12 years old get the 2 doses 6 months apart of either brand of HPV vaccine to protect against cervical cancer. Gardasil also protects against most genital warts, as well as some cancers of the vulva, vagina, and anus. Girls and young women ages 14 years or older should get 3 doses of an HPV vaccine(garasil) at 0, 2 & 6 months & for cervarix at 0,1 & 6 months if they have not received all doses yet.
  • 8.  Gardasil also protects against most genital warts, as well as some cancers of the vulva, vagina, and anus.  Girls and young women ages 14 years or older should get 3 doses of an HPV vaccine(gardasil) at 0, 2 & 6 months & for cervarix at 0,1 & 6 months if they have not received all doses yet. • Newer vaccines for HPV is gardasil 9 and cervavac • Gardasil 9 protects against 9 serotypes[6,11,16,18,31,33,45,52,58] and cervavac protects against 4 serotypes [6,11,16,18].