1. To make asynchronous serial communication using a microcontroller's USART, the transmitter must configure the baud rate generator and enable transmission by writing data to the transmit register, while the receiver must configure the baud rate generator and enable reception to read incoming data from the receive register.
2. Key steps include setting the SPBRG register and BRGH bit to determine the baud rate, enabling the serial port and transmission/reception, handling 9-bit data if needed, and checking status registers for transmission completion or errors.
3. Asynchronous serial communication allows microcontrollers to transmit data bit by bit over a single line using start and stop bits for synchronization instead of a separate clock line.