Datastax Enterprise 5.1 introduces enhancements like 3x faster operational analytics, improved multi-tenancy support, and advanced replication capabilities. Key updates include DSE analytics performance improvements, a new file system (DSEFS) compatible with HDFS, and features for DSE search and graph databases. Additional tools such as OpsCenter 6.1 and Studio 2.0 offer enhanced metrics, UI improvements, and better support for developers.